Padres vs. Mariners prediction: Seattle favored to win Monday's MLB matchup [8/25/2025]

The Seattle Mariners will face the San Diego Padres in MLB action at T-Mobile Park on Monday, commencing at 9:40PM ET.

Bryce Miller (2-5, 5.87 ERA) will be on the bump for the Mariners, while the Padres have opted for JP Sears (8-10, 4.94 ERA).

Based on updated simulations, Dimers' proven MLB model predicts the Mariners as the most likely winner of today's game.

For expanded analysis of Monday's matchup, including best bets and picks, visit our interactive Padres vs. Mariners predictions page.

Mariners vs. Padres prediction: Who will win, cover the run line?

Using powerful machine learning and data analysis, we have simulated the result of Monday's MLB matchup between the Padres and Mariners 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Mariners a 53% chance of beating the Padres.

According to our model, the Padres (+1.5) have a 64% chance of covering the run line, while the 8.5-run over/under has an equal 50-50 chance of hitting.

Padres vs. Mariners odds [8/25/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Padres	Mariners
Run Line	+1.5 (-194)	-1.5 (+165)
Moneyline	+108	-125
Total	o8.5 (-105)	u8.5 (-113)

All odds are correct at the time of publication and are subject to change.

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Padres vs. Mariners picks and best bets

Our model's strongest edge in today's Padres vs. Mariners matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets today

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Padres vs. Mariners game-day updates and essential details

Monday's MLB game between the Mariners and Padres at T-Mobile Park is scheduled to commence at 9:40PM ET.

• Who: San Diego Padres vs. Seattle Mariners
• Date: Monday, August 25, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: T-Mobile Park

Dimers.com's comprehensive preview of Monday's Padres vs. Mariners matchup includes our prediction, picks and the latest betting odds.

Before making any Padres vs. Mariners picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Mariners, with a 53% win probability, will likely beat the Padres on Monday.

AI and automation have enhanced this article to quickly deliver accurate Padres vs. Mariners insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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