Padres vs. Giants Prediction: San Francisco Predicted to Win Thursday's MLB Matchup [6/5/2025]

The San Francisco Giants and San Diego Padres are scheduled to meet in MLB action at Oracle Park on Thursday, starting at 3:45PM ET.

The Giants will have Robbie Ray (7-1, 2.43 ERA) as their starting pitcher, up against Dylan Cease (1-4, 4.66 ERA) for the Padres.

Based on the latest simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Giants as the most likely winner of today's game.

"Using the latest data, our experts simulated Thursday's San Diego-San Francisco game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Taking into account recent updates and various additional inputs, we forecast the Giants with a win probability of 52% and the Padres with 48%."

For a closer look at Thursday's matchup, including best bets and picks, visit our interactive Padres vs. Giants predictions page.

Giants vs. Padres Prediction: Who Will Win?

Using trusted machine learning and data, we have simulated the result of Thursday's MLB game between the Padres and Giants 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Giants a 52% chance of beating the Padres.

According to our model, the over/under total of 7 runs also has an equal 50-50 chance of hitting.

Padres vs. Giants Odds [6/5/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Padres	Giants
Moneyline	-104	-112
Total	o7 (-104)	u7 (-105)

All odds are correct at the time of publication and are subject to change.

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Padres vs. Giants Picks and Best Bets

Our model's biggest edge in today's Padres vs. Giants matchup is on the moneyline.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free MLB Picks

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Padres vs. Giants Game-Day Updates and Essential Details

Thursday's MLB game between the Giants and Padres at Oracle Park is scheduled to start at 3:45PM ET.

• Who: San Diego Padres vs. San Francisco Giants
• Date: Thursday, June 5, 2025
• Time: 3:45PM ET/12:45PM PT
• Venue: Oracle Park

Dimers.com's comprehensive preview of Thursday's Padres vs. Giants matchup includes our prediction, picks and the latest betting odds.

Before making any San Diego vs. San Francisco picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Giants, with a 52% win probability, will likely beat the Padres on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Padres vs. Giants insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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