Padres vs. Pirates Prediction: San Diego Predicted to Win Saturday's MLB Matchup [5/3/2025]

The Pittsburgh Pirates will take on the San Diego Padres, in what is expected to be a close MLB game, at PNC Park on Saturday, starting at 4:05PM ET.

The Pirates will have Bailey Falter (1-3, 5.93 ERA) as their starting pitcher, while the Padres have opted for Randy Vásquez (1-3, 4.28 ERA).

Based on the latest simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Padres as the most likely winner of today's game.

"Our team has used the latest data to run 10,000 simulations of Saturday's San Diego-Pittsburgh game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various other inputs, we estimate that the Padres are more likely to win, while the Pirates have a lower chance of victory."

For expanded analysis of Saturday's matchup, including best bets and picks, visit our interactive Padres vs. Pirates predictions page.

Pirates vs. Padres Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data analysis, we have simulated the outcome of Saturday's MLB matchup between the Padres and Pirates 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Padres a 51% chance of beating the Pirates.

According to our model, the Pirates (+1.5) have a 61% chance of covering the run line, while the over/under total of 9.5 runs has a 59% chance of staying under.

Padres vs. Pirates Odds [5/3/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Padres	Pirates
Run Line	-1.5 (+150)	+1.5 (-180)
Moneyline	+105	-115
Total	o9.5 (-105)	u9.5 (-115)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Padres vs. Pirates Picks and Best Bets

Our model's strongest edge in today's Padres vs. Pirates matchup is on the run line.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Padres vs. Pirates Game-Day Updates and Essential Details

Saturday's MLB game between the Pirates and Padres at PNC Park is scheduled to begin at 4:05PM ET.

• Who: San Diego Padres vs. Pittsburgh Pirates
• Date: Saturday, May 3, 2025
• Time: 4:05PM ET/1:05PM PT
• Venue: PNC Park

Dimers.com's full preview of Saturday's Padres vs. Pirates matchup includes our prediction, picks and the latest betting odds.

Before making any San Diego vs. Pittsburgh picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
• Understand where sports odds come from and how they're applied to baseball matchups
• Learn how to use Dimers Futures to find long-term betting opportunities as the World Series draws closer
• Stay informed with where online sports betting is currently legal and which betting sites are safest to use
• Boost your success with strategies to win at sports betting and explore why MLB is one of the best leagues to bet on

Sports Betting Deals Available for Saturday

To make the most of Saturday's exciting day of sports, headlined by a huge day of NBA and NHL playoffs action, check out details on the latest Bet365 bonus code "DIMERS" that secures the choice of two amazing signup promotions. Don't miss out!

Conclusion

We predict the Padres, with a 51% win probability, will likely beat the Pirates on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Padres vs. Pirates insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Stay up-to-date with the latest MLB news and MLB parlay picks throughout the season. Plus, our World Series odds provide the most up-to-date predictions for the World Series, American League, National League and each division.