Padres vs. Pirates Prediction: San Diego Predicted to Win Friday's MLB Matchup [5/2/2025]

The Pittsburgh Pirates will square off with the San Diego Padres in MLB action at PNC Park on Friday, beginning at 6:40PM ET.

The Pirates will send Mitch Keller (1-2, 3.97 ERA) to the mound, while the Padres have opted for Dylan Cease (1-2, 5.76 ERA).

Based on the latest simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Padres as the most likely winner of today's game.

"Employing the latest data, our experts simulated Friday's San Diego-Pittsburgh game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"After computing the latest updates and thousands of other inputs, we predict the Padres' chance of winning is 59%, while the Pirates' is 41%."

For further insights into Friday's matchup, including best bets and picks, visit our interactive Padres vs. Pirates predictions page.

Pirates vs. Padres Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and statistical analysis, we have simulated the outcome of Friday's MLB game between the Padres and Pirates 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Padres a 59% chance of defeating the Pirates.

According to our model, the Pirates (+1.5) have a 56% chance of covering the run line, while the 8.5-run over/under has a 57% chance of staying under.

Padres vs. Pirates Odds [5/2/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Padres	Pirates
Run Line	-1.5 (+126)	+1.5 (-148)
Moneyline	-134	+115
Total	o8.5 (-108)	u8.5 (-112)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Padres vs. Pirates Picks and Best Bets

Our model's biggest edge in today's Padres vs. Pirates matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Padres vs. Pirates Game-Day Updates and Essential Details

Friday's MLB game between the Pirates and Padres at PNC Park is scheduled to commence at 6:40PM ET.

• Who: San Diego Padres vs. Pittsburgh Pirates
• Date: Friday, May 2, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: PNC Park

Dimers.com's in-depth preview of Friday's Padres vs. Pirates matchup includes our prediction, picks and the latest betting odds.

Before making any San Diego vs. Pittsburgh picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
• Understand where sports odds come from and how they're applied to baseball matchups
• Learn how to use Dimers Futures to find long-term betting opportunities as the World Series draws closer
• Stay informed with where online sports betting is currently legal and which betting sites are safest to use
• Boost your success with strategies to win at sports betting and explore why MLB is one of the best leagues to bet on

Conclusion

We predict the Padres, with a 59% win probability, will likely beat the Pirates on Friday.

AI and automation have enhanced this article to quickly deliver accurate Padres vs. Pirates insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Keep up with the latest MLB news and MLB parlay picks throughout the season. Plus, our World Series odds offer the most accurate predictions for the World Series, American League, National League and each division.