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Padres vs. Yankees Prediction: Close Contest Projected After New Data Released for Tuesday's MLB Matchup [5/6/2025]

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Written by Jason Bevilacqua

Our expert prediction for Tuesday's San Diego Padres vs New York Yankees matchup.

San Diego Padres-New York Yankees Predictions and Game Preview.
Yankee Stadium sets the stage for the MLB matchup between the San Diego Padres and New York Yankees this Tuesday.

The New York Yankees will square off with the San Diego Padres in MLB action at Yankee Stadium on Tuesday, beginning at 7:05PM ET.

The Yankees will start Clarke Schmidt (0-1, 5.52 ERA), while the Padres have opted for Michael King (4-1, 2.10 ERA).

Based on updated simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts an equal chance for both the Yankees and Padres to win today's game.

"Our team has analyzed the latest data and conducted 10,000 simulations for Tuesday's San Diego-NY Yankees game," said Dimers' Chief Content Officer, Nick Slade.

"Based on the latest updates and extensive data, we predict a 50-50 chance for both the Yankees and Padres, making it a highly competitive matchup."

For a closer look at Tuesday's matchup, including best bets and picks, visit our interactive Padres vs. Yankees predictions page.

Yankees vs. Padres Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data, we have simulated the outcome of Tuesday's MLB matchup between the Padres and Yankees 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently can't split the two teams, giving both the Padres and Yankees a 50% chance of winning the game.

According to our model, the Yankees (+1.5) have a 63% chance of covering the run line, while the 8-run over/under has a 51% chance of going over.

 

Padres vs. Yankees Odds [5/6/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type Padres Yankees
Run Line -1.5 (+165) +1.5 (-200)
Moneyline +106 -120
Total o8 (-105) u8 (-110)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Padres vs. Yankees Picks and Best Bets

Our model's biggest edge in today's Padres vs. Yankees matchup is on the moneyline.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Video

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Padres vs. Yankees Game-Day Updates and Essential Details

Tuesday's MLB action between the Yankees and Padres at Yankee Stadium is scheduled to start at 7:05PM ET.

Dimers.com's full preview of Tuesday's Padres vs. Yankees matchup includes our prediction, picks and the latest betting odds.

Before making any San Diego vs. NY Yankees picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

Conclusion

We predict a close game between the Padres and Yankees on Tuesday, with each team having a 50% chance of winning.

AI and automation have enhanced this article to quickly deliver accurate Padres vs. Yankees insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Stay informed with the latest MLB betting news and MLB parlay picks throughout the season. Plus, our World Series odds offer the latest projections for the World Series, American League, National League and each division.

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Written by
Jason Bevilacqua
Head of Content and Communities

Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.

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