Padres vs. Mets prediction: Mets favored to win Tuesday's MLB matchup [9/16/2025]

The New York Mets will face the San Diego Padres, in what is expected to be a tight MLB game, at Citi Field on Tuesday, starting at 7:10PM ET.

The Mets will start Clay Holmes (11-8, 3.76 ERA), while the Padres have opted for Michael King (4-2, 2.87 ERA).

Based on the latest simulation results, Dimers' advanced MLB model projects the Mets as the most likely winner of today's game.

For expanded analysis of Tuesday's matchup, including best bets and picks, visit our interactive Padres vs. Mets predictions page.

Mets vs. Padres prediction: Who will win, cover the run line?

Using powerful machine learning and statistical analysis, we have simulated the result of Tuesday's MLB matchup between the Padres and Mets 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Mets a 53% chance of beating the Padres.

According to our model, the Padres (+1.5) have a 65% chance of covering the run line, while the 7.5-run over/under has a 58% chance of going over.

Padres vs. Mets odds [9/16/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Padres	Mets
Run Line	+1.5 (-225)	-1.5 (+170)
Moneyline	+104	-120
Total	o7.5 (-122)	u7.5 (+100)

All odds are correct at the time of publication and are subject to change.

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Padres vs. Mets picks and best bets

Our model's biggest edge in today's Padres vs. Mets matchup is on the run line.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Padres vs. Mets game-day updates and essential details

Tuesday's MLB action between the Mets and Padres at Citi Field is scheduled to commence at 7:10PM ET.

• Who: San Diego Padres vs. New York Mets
• Date: Tuesday, September 16, 2025
• Time: 7:10PM ET/4:10PM PT
• Venue: Citi Field

Dimers' in-depth preview of Tuesday's Padres vs. Mets matchup includes our prediction, picks and the latest betting odds.

Before making any Padres vs. Mets picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Mets, with a 53% win probability, will likely beat the Padres on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Padres vs. Mets insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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