Padres vs. Twins prediction: Why San Diego is favored to win Friday's MLB matchup [8/29/2025]

The Minnesota Twins will square off with the San Diego Padres, in what is expected to be a close MLB game, at Target Field on Friday, starting at 8:10PM ET.

The Twins will start Zebby Matthews (3-4, 5.30 ERA), while the Padres have opted for Nestor Cortes (2-2, 4.66 ERA).

Based on the latest simulation results, Dimers' proven MLB model projects the Padres as the most likely winner of today's game.

For further insights into Friday's matchup, including best bets and picks, visit our interactive Padres vs. Twins predictions page.

Twins vs. Padres prediction: Who will win, cover the run line?

Using innovative machine learning and data, we have simulated the result of Friday's MLB game between the Padres and Twins 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Padres a 52% chance of beating the Twins.

According to our model, the Twins (+1.5) have a 60% chance of covering the run line, while the over/under total of 8.5 runs has a 54% chance of going over.

Padres vs. Twins odds [8/29/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Padres	Twins
Run Line	-1.5 (+136)	+1.5 (-161)
Moneyline	-122	+110
Total	o8.5 (-120)	u8.5 (+101)

All odds are correct at the time of publication and are subject to change.

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Padres vs. Twins picks and best bets

Our model's biggest edge in today's Padres vs. Twins matchup is on the moneyline.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets today

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Padres vs. Twins game-day updates and essential details

Friday's MLB action between the Twins and Padres at Target Field is scheduled to start at 8:10PM ET.

• Who: San Diego Padres vs. Minnesota Twins
• Date: Friday, August 29, 2025
• Time: 8:10PM ET/5:10PM PT
• Venue: Target Field

Dimers.com's full preview of Friday's Padres vs. Twins matchup includes our prediction, picks and the latest betting odds.

Before making any Padres vs. Twins picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Padres, with a 52% win probability, will likely beat the Twins on Friday.

AI and automation have enhanced this article to quickly deliver accurate Padres vs. Twins insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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