Padres vs. Marlins Prediction: San Diego Predicted to Win Wednesday's MLB Matchup [7/23/2025]

The Miami Marlins will take on the San Diego Padres in MLB action at loanDepot park on Wednesday, starting at 12:10PM ET.

The Marlins will start Sandy Alcantara (4-9, 7.14 ERA), while the Padres will counter with Dylan Cease (3-9, 4.64 ERA).

Based on the latest simulations, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Padres as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Padres-Marlins game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Padres' chance of winning at 58%, with the Marlins at 42%."

For further insights into Wednesday's matchup, including best bets and picks, visit our interactive Padres vs. Marlins predictions page.

Marlins vs. Padres Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and statistical analysis, we have simulated the result of Wednesday's MLB matchup between the Padres and Marlins 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Padres a 58% chance of beating the Marlins.

According to our model, the Marlins (+1.5) have a 56% chance of covering the run line, while the 7.5-run over/under has a 51% chance of going over.

Padres vs. Marlins Odds [7/23/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Padres	Marlins
Run Line	-1.5 (+115)	+1.5 (-135)
Moneyline	-144	+122
Total	o7.5 (-112)	u7.5 (-102)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Padres vs. Marlins Picks and Best Bets

Our model's biggest edge in today's Padres vs. Marlins matchup is on the moneyline.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the free picks featured below.

Padres vs. Marlins Game-Day Updates and Essential Details

Wednesday's MLB action between the Marlins and Padres at loanDepot park is scheduled to commence at 12:10PM ET.

• Who: San Diego Padres vs. Miami Marlins
• Date: Wednesday, July 23, 2025
• Time: 12:10PM ET/9:10AM PT
• Venue: loanDepot park

Dimers.com's comprehensive preview of Wednesday's Padres vs. Marlins matchup includes our prediction, picks and the latest betting odds.

Before making any Padres vs. Marlins picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Padres, with a 58% win probability, will likely beat the Marlins on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Padres vs. Marlins insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Keep up with the latest MLB betting news and MLB parlay picks throughout the season. Plus, our World Series odds provide the latest predictions for the World Series, American League, National League and each division.