Padres vs. Marlins Prediction: Miami Predicted to Win Tuesday's MLB Matchup [7/22/2025]

MLB action continues on Tuesday at 6:40PM ET as the San Diego Padres square off with the Miami Marlins at loanDepot park.

Edward Cabrera (3-4, 3.61 ERA) will start on the mound for the Marlins, while the Padres are going with Stephen Kolek (3-4, 4.24 ERA).

Based on updated simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Marlins as the most likely winner of today's game.

For a closer look at Tuesday's matchup, including best bets and picks, visit our interactive Padres vs. Marlins predictions page.

Marlins vs. Padres Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data, we have simulated the result of Tuesday's MLB game between the Padres and Marlins 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Marlins a 53% chance of defeating the Padres.

According to our model, the Padres (+1.5) have a 66% chance of covering the run line, while the 8-run over/under has a 51% chance of staying under.

Padres vs. Marlins Odds [7/22/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Padres	Marlins
Run Line	+1.5 (-185)	-1.5 (+158)
Moneyline	+115	-132
Total	o8 (-102)	u8 (-105)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Padres vs. Marlins Picks and Best Bets

Our model's strongest edge in today's Padres vs. Marlins matchup is on the total.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Today

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Padres vs. Marlins Game-Day Updates and Essential Details

Tuesday's MLB action between the Marlins and Padres at loanDepot park is scheduled to commence at 6:40PM ET.

• Who: San Diego Padres vs. Miami Marlins
• Date: Tuesday, July 22, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: loanDepot park

Dimers.com's comprehensive preview of Tuesday's Padres vs. Marlins matchup includes our prediction, picks and the latest betting odds.

Before making any Padres vs. Marlins picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Marlins, with a 53% win probability, will likely beat the Padres on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Padres vs. Marlins insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Stay informed with the latest MLB betting news and MLB parlay picks throughout the season. Plus, our World Series odds offer the latest probabilities for the World Series, American League, National League and each division.