Padres vs. Marlins Prediction: Miami Predicted to Win Monday's MLB Matchup [7/21/2025]

The Miami Marlins will take on the San Diego Padres, in what is expected to be a tight MLB game, at loanDepot park on Monday, starting at 6:40PM ET.

The Marlins will send Eury Pérez (3-2, 3.18 ERA) to the mound, while the Padres will counter with Randy Vásquez (3-4, 3.80 ERA).

Based on the latest simulations, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Marlins as the most likely winner of today's game.

For further insights into Monday's matchup, including best bets and picks, visit our interactive Padres vs. Marlins predictions page.

Marlins vs. Padres Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and statistical analysis, we have simulated the result of Monday's MLB game between the Padres and Marlins 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Marlins a 54% chance of defeating the Padres.

According to our model, the Padres (+1.5) have a 63% chance of covering the run line, while the over/under total of 8 runs has an equal 50-50 chance of hitting.

Padres vs. Marlins Odds [7/21/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Padres	Marlins
Run Line	+1.5 (-176)	-1.5 (+155)
Moneyline	+120	-139
Total	o8 (-118)	u8 (-102)

All odds are correct at the time of publication and are subject to change.

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Padres vs. Marlins Picks and Best Bets

Our model's biggest edge in today's Padres vs. Marlins matchup is on the moneyline.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Today

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Padres vs. Marlins Game-Day Updates and Essential Details

Monday's MLB matchup between the Marlins and Padres at loanDepot park is scheduled to start at 6:40PM ET.

• Who: San Diego Padres vs. Miami Marlins
• Date: Monday, July 21, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: loanDepot park

Dimers.com's comprehensive preview of Monday's Padres vs. Marlins matchup includes our prediction, picks and the latest betting odds.

Before making any Padres vs. Marlins picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Marlins, with a 54% win probability, will likely beat the Padres on Monday.

AI and automation have enhanced this article to quickly deliver accurate Padres vs. Marlins insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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