Padres vs. Dodgers prediction: Dodgers predicted to win Saturday's MLB matchup [8/16/2025]

The Los Angeles Dodgers and San Diego Padres are scheduled to meet in MLB action at Dodger Stadium on Saturday, starting at 9:10PM ET.

The Dodgers will have Blake Snell (2-1, 2.37 ERA) as their starting pitcher, pitting him against Dylan Cease (5-10, 4.52 ERA) for the Padres.

Based on updated simulation results, Dimers' proven MLB model projects the Dodgers as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including best bets and picks, visit our interactive Padres vs. Dodgers predictions page.

Dodgers vs. Padres prediction: Who will win, cover the run line?

Using innovative machine learning and data analysis, we have simulated the outcome of Saturday's MLB matchup between the Padres and Dodgers 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Dodgers a 53% chance of beating the Padres.

According to our model, the Padres (+1.5) have a 66% chance of covering the run line, while the over/under total of 7.5 runs has an equal 50-50 chance of hitting.

Padres vs. Dodgers odds [8/16/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Padres	Dodgers
Run Line	+1.5 (-207)	-1.5 (+172)
Moneyline	+105	-120
Total	o7.5 (-115)	u7.5 (-102)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Padres vs. Dodgers picks and best bets

Our model's strongest edge in today's Padres vs. Dodgers matchup is on the run line.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets video

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Padres vs. Dodgers game-day updates and essential details

Saturday's MLB matchup between the Dodgers and Padres at Dodger Stadium is scheduled to begin at 9:10PM ET.

• Who: San Diego Padres vs. Los Angeles Dodgers
• Date: Saturday, August 16, 2025
• Time: 9:10PM ET/6:10PM PT
• Venue: Dodger Stadium

Dimers.com's comprehensive preview of Saturday's Padres vs. Dodgers matchup includes our prediction, picks and the latest betting odds.

Before making any Padres vs. Dodgers picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Sports betting deal available for Kansas and Illinois

To make the most of Saturday's enormous day of sports, headlined by a huge day of MLB, check out details on the latest Bet365 bonus available in the states of Kansas and Illinois that unlocks $150 in bonus bets from a $5 bet. Don't miss out!

Conclusion

We predict the Dodgers, with a 53% win probability, will likely beat the Padres on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Padres vs. Dodgers insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Stay informed with the latest MLB betting news and MLB parlay picks throughout the season. Plus, our World Series odds provide the most up-to-date predictions for the World Series, American League, National League and each division.