Padres vs. Rockies prediction: Why San Diego is favored to win Friday's MLB matchup [9/5/2025]

MLB action continues on Friday at 8:40PM ET as the favored San Diego Padres square off with the Colorado Rockies at Coors Field.

Kyle Freeland (3-14, 5.41 ERA) will get the ball for the Rockies, while the Padres are going with Nick Pivetta (13-4, 2.84 ERA).

Based on the latest simulations, Dimers' proven MLB model projects the Padres as the most likely winner of today's game.

For expanded analysis of Friday's matchup, including best bets and picks, visit our interactive Padres vs. Rockies predictions page.

Rockies vs. Padres prediction: Who will win, cover the run line?

Using innovative machine learning and statistical analysis, we have simulated the result of Friday's MLB game between the Padres and Rockies 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Padres a 63% chance of beating the Rockies.

According to our model, the Padres (-1.5) have a 53% chance of covering the run line, while the 10.5-run over/under has a 51% chance of going over.

Padres vs. Rockies odds [9/5/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Padres	Rockies
Run Line	-1.5 (-143)	+1.5 (+126)
Moneyline	-220	+184
Total	o10.5 (-110)	u10.5 (-104)

All odds are correct at the time of publication and are subject to change.

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Padres vs. Rockies picks and best bets

Our model's biggest edge in today's Padres vs. Rockies matchup is on the total.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Padres vs. Rockies game-day updates and essential details

Friday's MLB game between the Rockies and Padres at Coors Field is scheduled to start at 8:40PM ET.

• Who: San Diego Padres vs. Colorado Rockies
• Date: Friday, September 5, 2025
• Time: 8:40PM ET/5:40PM PT
• Venue: Coors Field

Dimers.com's full preview of Friday's Padres vs. Rockies matchup includes our prediction, picks and the latest betting odds.

Before making any Padres vs. Rockies picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Padres, with a 63% win probability, will likely beat the Rockies on Friday.

AI and automation have enhanced this article to quickly deliver accurate Padres vs. Rockies insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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