Padres vs. Reds Prediction: Cincinnati Predicted to Win Saturday's MLB Matchup [6/28/2025]

The Cincinnati Reds will square off with the San Diego Padres in MLB action at Great American Ball Park on Saturday, commencing at 4:10PM ET.

Andrew Abbott (7-1, 1.79 ERA) will start for the Reds, pitting him against Randy Vásquez (3-4, 3.60 ERA) for the Padres.

Based on updated simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Reds as the most likely winner of today's game.

"Our team has used the latest data to run 10,000 simulations of Saturday's Padres-Reds game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various other inputs, we estimate that the Reds are more likely to win, while the Padres have a lower chance of victory."

For further insights into Saturday's matchup, including best bets and picks, visit our interactive Padres vs. Reds predictions page.

Reds vs. Padres Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data, we have simulated the outcome of Saturday's MLB game between the Padres and Reds 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Reds a 56% chance of defeating the Padres.

According to our model, the Padres (+1.5) have a 61% chance of covering the run line, while the over/under total of 9.5 runs has a 55% chance of staying under.

Padres vs. Reds Odds [6/28/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Padres	Reds
Run Line	+1.5 (-145)	-1.5 (+133)
Moneyline	+132	-151
Total	o9.5 (-105)	u9.5 (-105)

All odds are correct at the time of publication and are subject to change.

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Padres vs. Reds Picks and Best Bets

Our model's biggest edge in today's Padres vs. Reds matchup is on the run line.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Video

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Padres vs. Reds Game-Day Updates and Essential Details

Saturday's MLB action between the Reds and Padres at Great American Ball Park is scheduled to start at 4:10PM ET.

• Who: San Diego Padres vs. Cincinnati Reds
• Date: Saturday, June 28, 2025
• Time: 4:10PM ET/1:10PM PT
• Venue: Great American Ball Park

Dimers.com's full preview of Saturday's Padres vs. Reds matchup includes our prediction, picks and the latest betting odds.

Before making any Padres vs. Reds picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Reds, with a 56% win probability, will likely beat the Padres on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Padres vs. Reds insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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