Padres vs. White Sox prediction: Why San Diego is favored to win Sunday's MLB matchup [9/21/2025]

MLB action continues on Sunday at 2:10PM ET as the San Diego Padres lock horns with the Chicago White Sox at Rate Field.

Sean Burke (4-10, 4.29 ERA) will start on the mound for the White Sox, while the Padres are going with Michael King (4-3, 3.84 ERA).

Based on the latest simulation results, Dimers' advanced MLB model predicts the Padres as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Padres-White Sox game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Padres with a win probability of 62%, while the White Sox have 38%."

For further insights into Sunday's matchup, including best bets and picks, visit our interactive Padres vs. White Sox predictions page.

White Sox vs. Padres prediction: Who will win, cover the run line?

Using powerful machine learning and data, we have simulated the outcome of Sunday's MLB matchup between the Padres and White Sox 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Padres a 62% chance of beating the White Sox.

According to our model, the White Sox (+1.5) have a 51% chance of covering the run line, while the over/under total of 8 runs has a 58% chance of going over.

Padres vs. White Sox odds [9/21/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Padres	White Sox
Run Line	-1.5 (-105)	+1.5 (-102)
Moneyline	-180	+155
Total	o8 (-118)	u8 (+100)

All odds are correct at the time of publication and are subject to change.

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Padres vs. White Sox picks and best bets

Our model's biggest edge in today's Padres vs. White Sox matchup is on the run line.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets video

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Padres vs. White Sox game-day updates and essential details

Sunday's MLB matchup between the White Sox and Padres at Rate Field is scheduled to start at 2:10PM ET.

• Who: San Diego Padres vs. Chicago White Sox
• Date: Sunday, September 21, 2025
• Time: 2:10PM ET/11:10AM PT
• Venue: Rate Field

Dimers' in-depth preview of Sunday's Padres vs. White Sox matchup includes our prediction, picks and the latest betting odds.

Before making any Padres vs. White Sox picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Padres, with a 62% win probability, will likely beat the White Sox on Sunday.

AI and automation have enhanced this article to quickly deliver accurate Padres vs. White Sox insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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