Padres vs. White Sox prediction: Why San Diego is favored to win Saturday's MLB matchup [9/20/2025]

The Chicago White Sox and San Diego Padres will meet in MLB action at Rate Field on Saturday, starting at 7:10PM ET.

The White Sox will have Yoendrys Gómez (3-2, 4.91 ERA) as their starting pitcher, up against Yu Darvish (4-5, 5.63 ERA) for the Padres.

Based on the latest simulation results, Dimers' advanced MLB model predicts the Padres as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including best bets and picks, visit our interactive Padres vs. White Sox predictions page.

White Sox vs. Padres prediction: Who will win, cover the run line?

Using trusted machine learning and statistical analysis, we have simulated the result of Saturday's MLB game between the Padres and White Sox 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Padres a 62% chance of defeating the White Sox.

According to our model, the White Sox (+1.5) have a 51% chance of covering the run line, while the 8-run over/under has a 59% chance of going over.

Padres vs. White Sox odds [9/20/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Padres	White Sox
Run Line	-1.5 (-106)	+1.5 (-105)
Moneyline	-185	+156
Total	o8 (-111)	u8 (-110)

All odds are correct at the time of publication and are subject to change.

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Padres vs. White Sox picks and best bets

Our model's biggest edge in today's Padres vs. White Sox matchup is on the run line.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Padres vs. White Sox game-day updates and essential details

Saturday's MLB matchup between the White Sox and Padres at Rate Field is scheduled to begin at 7:10PM ET.

• Who: San Diego Padres vs. Chicago White Sox
• Date: Saturday, September 20, 2025
• Time: 7:10PM ET/4:10PM PT
• Venue: Rate Field

Dimers' full preview of Saturday's Padres vs. White Sox matchup includes our prediction, picks and the latest betting odds.

Before making any Padres vs. White Sox picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Padres, with a 62% win probability, will likely beat the White Sox on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Padres vs. White Sox insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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