Padres vs. White Sox prediction: Why San Diego is favored to win Friday's MLB matchup [9/19/2025]

The Chicago White Sox and San Diego Padres are scheduled to meet in MLB action at Rate Field on Friday, starting at 7:40PM ET.

The White Sox will send Davis Martin (6-10, 4.01 ERA) to the mound, while the Padres will counter with Dylan Cease (8-11, 4.59 ERA).

Based on updated simulation results, Dimers' proven MLB model projects the Padres as the most likely winner of today's game.

For expanded analysis of Friday's matchup, including best bets and picks, visit our interactive Padres vs. White Sox predictions page.

White Sox vs. Padres prediction: Who will win, cover the run line?

Using trusted machine learning and data analysis, we have simulated the result of Friday's MLB matchup between the Padres and White Sox 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Padres a 63% chance of beating the White Sox.

According to our model, the Padres (-1.5) have a 51% chance of covering the run line, while the 8-run over/under has a 55% chance of going over.

Padres vs. White Sox odds [9/19/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Padres	White Sox
Run Line	-1.5 (-115)	+1.5 (+104)
Moneyline	-190	+160
Total	o8 (-115)	u8 (-102)

All odds are correct at the time of publication and are subject to change.

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Padres vs. White Sox picks and best bets

Our model's biggest edge in today's Padres vs. White Sox matchup is on the run line.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

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Padres vs. White Sox game-day updates and essential details

Friday's MLB action between the White Sox and Padres at Rate Field is scheduled to start at 7:40PM ET.

• Who: San Diego Padres vs. Chicago White Sox
• Date: Friday, September 19, 2025
• Time: 7:40PM ET/4:40PM PT
• Venue: Rate Field

Dimers' in-depth preview of Friday's Padres vs. White Sox matchup includes our prediction, picks and the latest betting odds.

Before making any Padres vs. White Sox picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Padres, with a 63% win probability, will likely beat the White Sox on Friday.

AI and automation have enhanced this article to quickly deliver accurate Padres vs. White Sox insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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