Padres vs. Diamondbacks Prediction: San Diego Predicted to Win Wednesday's MLB Matchup [8/6/2025]

The Arizona Diamondbacks will face the San Diego Padres in MLB action at Chase Field on Wednesday, starting at 9:40PM ET.

Anthony DeSclafani (1-2, 4.91 ERA) will start for the Diamondbacks, while the Padres will counter with Nestor Cortes (1-1, 9.00 ERA).

Based on updated simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Padres as the most likely winner of today's game. "Our team has simulated the outcome of Wednesday's Padres-Diamondbacks game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Padres' chance of winning at 56%, with the Diamondbacks at 44%."

For a closer look at Wednesday's matchup, including best bets and picks, visit our interactive Padres vs. Diamondbacks predictions page.

Diamondbacks vs. Padres Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data analysis, we have simulated the result of Wednesday's MLB matchup between the Padres and Diamondbacks 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Padres a 56% chance of defeating the Diamondbacks.

According to our model, the Diamondbacks (+1.5) have a 56% chance of covering the run line, while the 9.5-run over/under has an equal 50-50 chance of hitting.

Padres vs. Diamondbacks Odds [8/6/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Padres	Diamondbacks
Run Line	-1.5 (+115)	+1.5 (-137)
Moneyline	-135	+116
Total	o9.5 (-102)	u9.5 (-115)

All odds are correct at the time of publication and are subject to change.

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Padres vs. Diamondbacks Picks and Best Bets

Our model's strongest edge in today's Padres vs. Diamondbacks matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Padres vs. Diamondbacks Game-Day Updates and Essential Details

Wednesday's MLB game between the Diamondbacks and Padres at Chase Field is scheduled to begin at 9:40PM ET.

• Who: San Diego Padres vs. Arizona Diamondbacks
• Date: Wednesday, August 6, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: Chase Field

Dimers.com's full preview of Wednesday's Padres vs. Diamondbacks matchup includes our prediction, picks and the latest betting odds.

Before making any Padres vs. Diamondbacks picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Padres, with a 56% win probability, will likely beat the Diamondbacks on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Padres vs. Diamondbacks insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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