Padres vs. Diamondbacks Prediction: San Diego Predicted to Win Tuesday's MLB Matchup [8/5/2025]

MLB action continues on Tuesday at 9:40PM ET as the San Diego Padres lock horns with the Arizona Diamondbacks at Chase Field.

Ryne Nelson (6-3, 3.20 ERA) will start on the mound for the Diamondbacks, while the Padres will counter with Yu Darvish (1-3, 6.46 ERA).

Based on updated simulations, Dimers' proven MLB model (see Dimers Pro for full access) projects the Padres as the most likely winner of today's game.

For expanded analysis of Tuesday's matchup, including best bets and picks, visit our interactive Padres vs. Diamondbacks predictions page.

Diamondbacks vs. Padres Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data analysis, we have simulated the result of Tuesday's MLB matchup between the Padres and Diamondbacks 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Padres a 54% chance of beating the Diamondbacks.

According to our model, the Diamondbacks (+1.5) have a 58% chance of covering the run line, while the 9-run over/under has an equal 50-50 chance of hitting.

Padres vs. Diamondbacks Odds [8/5/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Padres	Diamondbacks
Run Line	-1.5 (+135)	+1.5 (-154)
Moneyline	-121	+108
Total	o9 (+101)	u9 (-120)

All odds are correct at the time of publication and are subject to change.

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Padres vs. Diamondbacks Picks and Best Bets

Our model's strongest edge in today's Padres vs. Diamondbacks matchup is on the run line.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Today

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Padres vs. Diamondbacks Game-Day Updates and Essential Details

Tuesday's MLB action between the Diamondbacks and Padres at Chase Field is scheduled to start at 9:40PM ET.

• Who: San Diego Padres vs. Arizona Diamondbacks
• Date: Tuesday, August 5, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: Chase Field

Dimers.com's comprehensive preview of Tuesday's Padres vs. Diamondbacks matchup includes our prediction, picks and the latest betting odds.

Before making any Padres vs. Diamondbacks picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Padres, with a 54% win probability, will likely beat the Diamondbacks on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Padres vs. Diamondbacks insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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