Padres vs. Diamondbacks Prediction: San Diego Predicted to Win Monday's MLB Matchup [8/4/2025]

MLB action continues on Monday at 9:40PM ET as the San Diego Padres square off with the Arizona Diamondbacks at Chase Field.

The Diamondbacks will start Brandon Pfaadt (10-7, 5.11 ERA), pitting him against JP Sears (7-9, 4.95 ERA) for the Padres.

Based on updated simulations, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Padres as the most likely winner of today's game.

For further insights into Monday's matchup, including best bets and picks, visit our interactive Padres vs. Diamondbacks predictions page.

Diamondbacks vs. Padres Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data, we have simulated the outcome of Monday's MLB matchup between the Padres and Diamondbacks 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Padres a 54% chance of beating the Diamondbacks.

According to our model, the Diamondbacks (+1.5) have a 58% chance of covering the run line, while the 9-run over/under has a 53% chance of going over.

Padres vs. Diamondbacks Odds [8/4/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Padres	Diamondbacks
Run Line	-1.5 (+125)	+1.5 (-146)
Moneyline	-130	+110
Total	o9 (-119)	u9 (+100)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Padres vs. Diamondbacks Picks and Best Bets

Our model's strongest edge in today's Padres vs. Diamondbacks matchup is on the run line.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Padres vs. Diamondbacks Game-Day Updates and Essential Details

Monday's MLB game between the Diamondbacks and Padres at Chase Field is scheduled to start at 9:40PM ET.

• Who: San Diego Padres vs. Arizona Diamondbacks
• Date: Monday, August 4, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: Chase Field

Dimers.com's comprehensive preview of Monday's Padres vs. Diamondbacks matchup includes our prediction, picks and the latest betting odds.

Before making any Padres vs. Diamondbacks picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Padres, with a 54% win probability, will likely beat the Diamondbacks on Monday.

AI and automation have enhanced this article to quickly deliver accurate Padres vs. Diamondbacks insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Stay informed with the latest MLB news and MLB parlay picks throughout the season. Plus, our World Series odds provide the most up-to-date projections for the World Series, American League, National League and each division.