Samford vs. Western Carolina prediction: Why Western Carolina is favored to win in college football Week 4, 2025

Western Carolina will take on Samford in Week 4 college football action at Bob Waters Field at E.J. Whitmire Stadium on Saturday, commencing at 2:30PM ET.

Based on updated simulations, Dimers' proven college football model predicts Western Carolina as the most likely winner of today's game.

For a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Samford vs. Western Carolina predictions page.

Samford vs. Western Carolina prediction: Who will win, cover the spread?

Using trusted machine learning and data, we have simulated the result of Samford vs. Western Carolina 10,000 times as part of our college football predictions coverage.

Our famous predictive model currently gives Western Carolina a 73% chance of defeating Samford. Our predicted final score has Western Carolina winning 34-23.

According to our model, the bookmakers have got it right, and Samford and Western Carolina each have a 50% chance of covering the spread, while the over/under total of 60.5 points has a 59% chance of going over.

Samford vs. Western Carolina odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	Samford	Western Carolina
Spread	+10.5 (-110)	-10.5 (-110)
Moneyline	+350	-365
Total	o60.5 (-110)	u60.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Samford vs. Western Carolina picks and best bets

Our model's biggest edge in today's Samford vs. Western Carolina matchup is on the spread.

Our expert predictions, aligned with the latest odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Samford vs. Western Carolina game-day updates and essential details

Saturday's college football action between Western Carolina and Samford at Bob Waters Field at E.J. Whitmire Stadium is scheduled to commence at 2:30PM ET.

• Who: Samford vs. Western Carolina
• Date: Saturday, September 20, 2025
• Time: 2:30PM ET/11:30AM PT
• Venue: Bob Waters Field at E.J. Whitmire Stadium

Dimers' in-depth preview of Saturday's Samford vs. Western Carolina matchup includes our prediction, picks and the latest betting odds.

Before making any Samford vs. Western Carolina picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Western Carolina, with a 73% win probability, will likely beat Samford on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Samford vs. Western Carolina insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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