Real Madrid vs. Espanyol prediction, odds, La Liga picks [9/20/2025]

La Liga action continues on Saturday at 10:15AM ET as Espanyol faces off with the favored Real Madrid at Estadio Santiago Bernabéu.

Based on the latest simulations, Dimers' advanced La Liga model projects Real Madrid as the most likely winner of today's game.

For further insights into Saturday's matchup, including best bets and picks, visit our interactive Real Madrid vs. Espanyol predictions page.

Real Madrid vs. Espanyol prediction: Who will win?

Using innovative machine learning and data, we have simulated the result of Saturday's La Liga match between Real Madrid and Espanyol 10,000 times as part of our La Liga predictions coverage.

Our independent predictive model currently indicates a 74.3% chance of Real Madrid winning, a 10.2% chance for Espanyol, and a 15.4% chance of a draw.

Real Madrid vs. Espanyol odds

We have researched the best La Liga odds in America for this game, which are listed here:

Market	Real Madrid	Espanyol	Draw
Moneyline	-475	+1200	+600

All odds are correct at the time of publication and are subject to change.

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Real Madrid vs. Espanyol picks and best bets

Our model's strongest edge in today's Real Madrid vs. Espanyol matchup is on the moneyline.

Our expert predictions, matched against the current odds, reveal the best La Liga picks and La Liga best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Real Madrid vs. Espanyol: Correct score and BTTS predictions

The top three most likely final scores, according to our model, are listed below, with a 2-0 Real Madrid win being the most probable:

Final Score	Probability
MAD 2-0 ESP	10.7%
MAD 2-1 ESP	9.2%
MAD 3-0 ESP	9.2%

When it comes to the both teams to score (BTTS) market, we project a 53.2% chance that both teams scoring, and a 46.8% probability of at least one team keeping a clean sheet.

These predictions are based on each team's average score after 10,000 simulations.

Real Madrid vs. Espanyol game-day updates and essential details

Saturday's La Liga action between Real Madrid and Espanyol at Estadio Santiago Bernabéu is scheduled to begin in the USA at 10:15AM ET.

• Who: Real Madrid vs. Espanyol
• Date: Saturday, September 20, 2025
• Time: 10:15AM ET/7:15AM PT
• Venue: Estadio Santiago Bernabéu

Dimers' full preview of Saturday's Real Madrid vs. Espanyol matchup includes our prediction, picks and the latest betting odds.

Before making any Espanyol vs. Real Madrid picks, be sure to check out the latest La Liga predictions and betting advice from Dimers Pro.

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Conclusion

According to our computer model, Real Madrid has a 74.3% win probability on Saturday, Espanyol has a 10.2% win probability, and there is a 15.4% chance that the game will end in a draw.

AI and automation have enhanced this article to quickly deliver accurate Real Madrid vs. Espanyol insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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