Rams vs. 49ers Predictions and Odds - Nov 15, 2021

The San Francisco 49ers take on the Los Angeles Rams in NFL Week 10 action at Levi's Stadium on Monday, beginning at 8:15 PM EST.

Dimers' free betting picks for Rams vs. 49ers, as well as game predictions and best odds, are detailed below.

Who will win Rams vs. 49ers?

Based on advanced computer power and data, Dimers.com has simulated Monday's Rams-49ers matchup 10,000 times.

Dimers' credible and independent predictive analytics model, DimersBOT, gives the Rams a 64% chance of beating the 49ers.

MORE: Full betting guide for Rams vs. 49ers

Rams vs. 49ers Point Spread, Moneyline and Over/Under

The 49ers are +3.5 underdogs at home to the Rams, with -105 at DraftKings Sportsbook the best odds available.

For the favored Rams (-3.5) to cover the spread, PointsBet has the best odds on offer at +100.

DraftKings Sportsbook has the best moneyline odds for the 49ers at +160. That means you can bet $100 to profit $160, earning a total payout of $260, if they win.

Elsewhere, BetMGM has the best moneyline odds for the Rams at -182, where you can risk $182 to win $100, for a total payout of $282, if they come out on top.

The Over/Under sits at 50.5 with BetMGM, which has the best odds for the Over at -110, as well as the best odds for the Under at -110.

As always, make sure you check all the sportsbooks that are available in your state for the best NFL odds and lines.

According to DimersBOT, the Rams (-3.5) are a 59% chance of covering the spread, while the 50.5-point Over/Under is a 53% chance of going Under.

Best Bets for Rams vs. 49ers

• Spread: Rams -3.5 at +100 with PointsBet (59% probability) 🔥
• Moneyline: Rams Win at -182 with BetMGM (64% probability)
• Over/Under: Under 50.5 at -110 with BetMGM (53% probability)

Any time you see a 🔥, that means it's one of Dimers' best bets today across all major pro and college sports.

MORE: Best bets today for all major pro and college sports

Rams vs. 49ers Score Prediction

Dimers.com's predicted final score for LA Rams vs. San Francisco at Levi's Stadium this Monday has the Rams winning 27-22.

Dimers has full coverage of this week's Rams-49ers game, including pre-game predictions, best betting picks, and live win probabilities.

Don't forget, DimersBOT updates often, so keep an eye on this page for the latest ahead of Rams vs. 49ers on Monday November 15, 2021.

Rams vs. 49ers 2021 Game Info

When do the 49ers play the Rams?

• Date: Monday November 15, 2021
• Time: 8:15 PM EST / 5:15 PM PST
• Venue: Levi's Stadium

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