Purdue vs. Notre Dame prediction: Notre Dame favored to win in college football Week 4, 2025

Notre Dame and Purdue will lock horns in Week 4 college football action at Notre Dame Stadium on Saturday, starting at 3:30PM ET.

Based on the latest simulations, Dimers' advanced college football model predicts Notre Dame as the most likely winner of today's game.

For further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Purdue vs. Notre Dame predictions page.

Purdue vs. Notre Dame prediction: Who will win, cover the spread?

Using powerful machine learning and statistical analysis, we have simulated the result of Purdue vs. Notre Dame 10,000 times as part of our college football predictions coverage.

Our independent predictive model currently gives Notre Dame a 94% chance of defeating Purdue. Our predicted final score has Notre Dame winning 38-13.

According to our model, the bookmakers have got it right, and Purdue and Notre Dame each have a 50% chance of covering the spread, while the over/under total of 51.5 points has a 53% chance of staying under.

Purdue vs. Notre Dame odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	Purdue	Notre Dame
Spread	+24.5 (-102)	-24.5 (-112)
Moneyline	+1400	-2400
Total	o51.5 (-110)	u51.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Purdue vs. Notre Dame picks and best bets

Our model's biggest edge in today's Purdue vs. Notre Dame matchup is on the spread.

Our expert predictions, matched against the latest odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Purdue vs. Notre Dame game-day updates and essential details

Saturday's college football matchup between Notre Dame and Purdue at Notre Dame Stadium is scheduled to commence at 3:30PM ET.

• Who: Purdue vs. Notre Dame
• Date: Saturday, September 20, 2025
• Time: 3:30PM ET/12:30PM PT
• Venue: Notre Dame Stadium

Dimers' full preview of Saturday's Purdue vs. Notre Dame matchup includes our prediction, picks and the latest betting odds.

Before making any Purdue vs. Notre Dame picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Notre Dame, with a 94% win probability, will likely beat Purdue on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Purdue vs. Notre Dame insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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