Puebla vs. Santos Laguna Prediction, Odds, Liga MX Picks [7/25/2025]

Puebla will take on Santos Laguna in Liga MX action at Estadio Cuauhtémoc on Friday, commencing at 9:00PM ET.

Based on updated simulations, Dimers' advanced Liga MX model (see Dimers Pro for full access) predicts Puebla as the most likely winner of today's game.

For further insights into Friday's matchup, including best bets and picks, visit our interactive Puebla vs. Santos Laguna predictions page.

Puebla vs. Santos Laguna Prediction: Who Will Win?

Using innovative machine learning and data analysis, we have simulated the outcome of Friday's Liga MX matchup between Puebla and Santos Laguna 10,000 times as part of our Liga MX predictions coverage.

Our independent predictive model indicates a 52.5% chance of Puebla winning, a 23.3% chance for Santos Laguna, and a 24.3% chance of a draw.

Additionally, the 2.5-goal over/under has a 51% chance of going over, according to our model.

Puebla vs. Santos Laguna Odds

We have sourced the best Liga MX odds in America for this game, which are listed here:

Moneyline

Puebla	Santos Laguna	Draw
-110	+295	+250

Total Goals

Over 2.5	Under 2.5
-120	-115

All odds are correct at the time of publication and are subject to change.

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Puebla vs. Santos Laguna Picks and Best Bets

Our model's strongest edge in today's Puebla vs. Santos Laguna matchup is on the moneyline.

Our expert predictions, matched against the latest odds, reveal the best Liga MX picks and Liga MX best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Puebla vs. Santos Laguna: Correct Score and BTTS Predictions

Here are the top three most likely final scores according to our model, with a 1-1 draw being the most probable:

Final Score	Probability
PUE 1-1 SLA	11.5%
PUE 1-0 SLA	11.2%
PUE 2-1 SLA	9.7%

When it comes to the both teams to score (BTTS) market, we project a 52.2% chance that both Puebla and Santos Laguna score, and a 47.8% probability of at least one team being held goalless.

These predictions are based on each team's average score after 10,000 simulations, meaning the most likely correct score may differ from our predicted winner.

Puebla vs. Santos Laguna Game-Day Updates and Essential Details

Friday's game between Puebla and Santos Laguna at Estadio Cuauhtémoc is scheduled to begin at 9:00PM ET.

• Who: Puebla vs. Santos Laguna
• Date: Friday, July 25, 2025
• Time: 9:00PM ET/6:00PM PT
• Venue: Estadio Cuauhtémoc

Dimers.com's in-depth preview of Friday's Puebla vs. Santos Laguna matchup includes our prediction, picks and the latest betting odds.

Before making any Santos Laguna vs. Puebla picks, be sure to check out the latest Liga MX predictions and betting advice from Dimers Pro.

Conclusion

According to our computer model, Puebla has a 52.5% win probability on Friday, Santos Laguna has a 23.3% win probability, and there is a 24.3% chance that the game will end in a draw.

AI and automation have enhanced this article to quickly deliver accurate Puebla vs. Santos Laguna insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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