Puebla vs. Guadalajara prediction, odds, Liga MX picks [9/26/2025]

Puebla will square off with Guadalajara in Liga MX action on Friday, commencing at 11:00PM ET.

Based on updated simulations, Dimers' advanced Liga MX model projects Guadalajara as the most likely winner of today's game.

For expanded analysis of Friday's matchup, including best bets and picks, visit our interactive Puebla vs. Guadalajara predictions page.

Puebla vs. Guadalajara prediction: Who will win?

Using powerful machine learning and data, we have simulated the outcome of Friday's Liga MX game between Puebla and Guadalajara 10,000 times as part of our Liga MX predictions coverage.

Our leading predictive model currently suggests a 29.7% chance of Puebla winning, a 44.5% chance for Guadalajara, and a 25.8% chance of a draw.

Additionally, the over/under total of 2.5 goals has a 51% chance of staying under, according to our model.

Puebla vs. Guadalajara odds

We have researched the best Liga MX odds in America for this game, which are listed here:

Moneyline

Puebla	Guadalajara	Draw
+240	+115	+240

Total Goals

Over 2.5	Under 2.5
-105	-114

All odds are correct at the time of publication and are subject to change.

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Puebla vs. Guadalajara picks and best bets

Our model's biggest edge in today's Puebla vs. Guadalajara matchup is on the moneyline.

Our expert predictions, matched against the current odds, reveal the best Liga MX picks and Liga MX best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Puebla vs. Guadalajara: Correct score and BTTS predictions

The top three most likely final scores, according to our model, are listed below, with a 1-1 draw being the most probable:

Final Score	Probability
PUE 1-1 GUA	12.3%
PUE 0-1 GUA	10.6%
PUE 1-2 GUA	9.1%

When it comes to the both teams to score (BTTS) market, we project a 52.8% chance that both Puebla and Guadalajara score, and a 47.2% probability of at least one team being held goalless.

These predictions are based on each team's average score after 10,000 simulations, which means the most likely correct score may differ from our predicted winner.

Puebla vs. Guadalajara game-day updates and essential details

Friday's game between Puebla and Guadalajara is scheduled to start at 11:00PM ET.

• Who: Puebla vs. Guadalajara
• Date: Friday, September 26, 2025
• Time: 11:00PM ET/8:00PM PT

Dimers' full preview of Friday's Puebla vs. Guadalajara matchup includes our prediction, picks and the latest betting odds.

Before making any Guadalajara vs. Puebla picks, be sure to check out the latest Liga MX predictions and betting advice from Dimers Pro.

Conclusion

According to our computer model, Puebla has a 29.7% win probability on Friday, Guadalajara has a 44.5% win probability, and there is a 25.8% chance that the game will end in a draw.

AI and automation have enhanced this article to quickly deliver accurate Puebla vs. Guadalajara insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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