Premier League Betting Tips: Friday's Picks Include Two Moneyline Plays [5/16/2025]

Premier League betting returns with another attractive slate on 5/16, and we're here to share our top picks for Friday's English soccer action.

Today's Premier League best bets include matchups like Tottenham vs. Aston Villa and Manchester United vs. Chelsea, with this article updated throughout the day to feature the highest-probability plays based on thousands of data-driven simulations from our predictive analytics model.

But if you're serious about long-term profit, it's not just about probability—it's about edge. To unlock our highest-edge Premier League bets—the ones with true long-term value—join Dimers Pro.

Pro members get unlimited access to everything Dimers has to offer on Friday, May 16, 2025, including our full set of Premier League picks and best bets.

List of Premier League Betting Tips Today [5/16, Updated 2:03PM ET]

After diving deep into the numbers and conducting thousands of simulations, our famous predictive analytics model has identified the best English soccer bets for Friday, May 16, 2025.

While these picks are sorted by probability, the real edge—the bets with the highest long-term value—is reserved for Dimers Pro subscribers. Because smart betting isn't just about what's likely—it's about what's profitable.

Tottenham ML (+900)

• Probability: 17.3%
• Edge: 7.3%
• Matchup: Tottenham vs. Aston Villa (2:30PM ET, Friday)

Our model has pinpointed a high-probability Premier League betting opportunity today, which comes in the Tottenham vs. Aston Villa game. We recommend a bet on the Tottenham ML at +900 odds, with our analysis showing a 17.3% chance of hitting and a compelling edge of 7.3%.

Manchester United ML (+490)

• Probability: 20.6%
• Edge: 3.6%
• Matchup: Manchester United vs. Chelsea (3:15PM ET, Friday)

Our model has found another strong Premier League bet for Friday's sports action, this time in the matchup between Manchester United and Chelsea. We suggest placing a wager on Manchester United ML at +490 odds, with a 20.6% probability delivering a 3.6% edge.

MORE: Friday's Player Prop Picks

Premier League Best Bets: Friday, 5/16/2025

As of 2:03PM ET, here are our top two Premier League bets by probability recommended by our model:

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Dimers Pro unlocks instant access to the most valuable bets across all sports, powered by our advanced predictive model.

Today, Dimers Pro subscribers have access to two Premier League picks—with access to all of these being what makes a difference over time.

Join Dimers Pro now to access these picks, as well as a comprehensive range of props, trends and parlays for May 16, 2025.

List of Upcoming Premier League Games to Bet On [5/16/2025]

• Tottenham vs. Aston Villa (2:30PM ET, Friday)
• Manchester United vs. Chelsea (3:15PM ET, Friday)

More on Premier League

The best on this page form part of our Premier League best bets series.

For more Premier League betting content, we have Premier League betting news and the latest Premier League title odds and predictions.

Conclusion

Our Premier League best bets are locked and loaded for May 16, 2025, featuring plays such as Tottenham ML and Manchester United ML. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate Premier League insights quickly, with human oversight ensuring high editorial quality. Our predictions are drawn from current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.