Premier League betting tips: Sunday's picks include two moneyline plays [9/21/2025]

Today’s Premier League betting tips for September 21, 2025 are here, with Sunday’s Premier League best bets backed by tens of thousands of predictive simulations analyzing the latest odds and matchups.

These Premier League best bets include matchups like Newcastle vs. Bournemouth and Aston Villa vs. Sunderland, with this article updated throughout the day to feature the highest-probability plays based on thousands of data-driven simulations from our predictive analytics model.

But if you're serious about long-term profit, it's not just about probability—it's about edge. To unlock our highest-edge Premier League bets—the ones with true long-term value—join Dimers Pro.

Pro members get unlimited access to everything Dimers has to offer on Sunday, September 21, 2025, including our complete suite of picks and best bets for today and the week ahead.

List of Premier League betting tips today [9/21, updated 8:32AM ET]

After diving deep into the numbers and conducting thousands of simulations, our famous predictive analytics model has identified the best English soccer bets for Sunday, September 21, 2025.

Newcastle vs. Bournemouth over 2.5 goals (-106)

• Probability: 55.3%
• Edge: 3.9%
• Matchup: Newcastle vs. Bournemouth (9:00AM ET, Sunday)

Our model has pinpointed a high-probability Premier League betting opportunity today, which comes in the Newcastle vs. Bournemouth matchup. We recommend an over/under bet on over 2.5 goals at -106 odds, with our analysis showing a 55.3% chance of hitting and a compelling edge of 3.9%.

Aston Villa ML (+120)

• Probability: 49.3%
• Edge: 3.8%
• Matchup: Aston Villa vs. Sunderland (9:00AM ET, Sunday)

Our model has found another strong Premier League bet for Sunday's sports action, this time in the game between Aston Villa and Sunderland. We suggest placing a wager on Aston Villa ML at +120 odds, with a 49.3% probability delivering a 3.8% edge.

Newcastle ML (+230)

• Probability: 38.5%
• Edge: 8.2%
• Matchup: Newcastle vs. Bournemouth (9:00AM ET, Sunday)

Our model has found another strong Premier League bet for today's sports action, this time in the Newcastle vs. Bournemouth matchup. We recommend a bet on Newcastle ML at +230 odds. Our projections shows a 38.5% probability and 8.2% edge for this wager.

Premier League best bets: Sunday, 9/21/2025

As of 8:32AM ET, here are our top three Premier League bets by probability recommended by our model:

Matchup	Bet	Odds	Probability	Edge
Newcastle vs. Bournemouth	Over 2.5 Goals	-106 @ FanDuel	55.3%	3.9%
Aston Villa vs. Sunderland	Aston Villa ML	+120 @ FanDuel	49.3%	3.8%
Newcastle vs. Bournemouth	Newcastle ML	+230 @ FanDuel	38.5%	8.2%

Dimers Pro unlocks instant access to the most valuable bets across all sports, powered by our advanced predictive model.

Today, Dimers Pro subscribers have access to three Premier League picks—with access to all of these being what makes a difference over time.

Join Dimers Pro now to access these picks, as well as a comprehensive range of props, trends and parlays for September 21, 2025.

List of upcoming Premier League games to bet on [9/21/2025]

• Newcastle vs. Bournemouth (9:00AM ET, Sunday)
• Aston Villa vs. Sunderland (9:00AM ET, Sunday)
• Manchester City vs. Arsenal (11:30AM ET, Sunday)

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More about Premier League

The bets on this page form part of our Premier League best bets series.

For more Premier League betting content, we have Premier League betting news and the latest Premier League title odds and predictions.

Conclusion

Our Premier League best bets are locked and loaded for September 21, 2025, featuring plays such as over 2.5 goals in the Newcastle vs. Bournemouth matchup and Aston Villa ML. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate Premier League insights quickly, with human oversight ensuring high editorial quality. Our predictions are based on current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

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