Pittsburgh Steelers vs. New England Patriots early prediction: Expert picks for NFL Week 3, 2025

The Pittsburgh Steelers and New England Patriots will meet in Week 3 of the NFL season at Gillette Stadium on Sunday, September 21, 2025, starting at 1:00PM ET.

Initial simulations from Dimers' trusted NFL model favor the Patriots as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Steelers vs. Patriots predictions page.

Pittsburgh vs. New England early predictions

Leveraging trusted machine learning and analysis, we have simulated the Steelers vs. Patriots game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Steelers 45%, Patriots 55%
• Predicted final score: Steelers 20-22 Patriots
• Spread: Steelers (+1.5) 50%, Patriots (-1.5) 50%
• Total points (43.5): Over 50%, Under 50%

As of September 14, 2025, these Steelers-Patriots numbers and predictions reflect the latest data and insights available.

Steelers vs. Patriots Week 3 details

The NFL Week 3 game between the Patriots and Steelers at Gillette Stadium is scheduled for September 21, 2025.

• Who: Pittsburgh Steelers vs. New England Patriots
• Date: Sunday, September 21, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Gillette Stadium

Steelers vs. Patriots opening odds

We've researched the best betting odds across America for this Week 3 game, which are listed here:

• Spread: Steelers +1.5 (-110), Patriots -1.5 (-110)
• Moneyline: Steelers +105, Patriots -125
• Total: Over/Under 43.5 (-110/-110)

Odds may continue to move—track live changes via our NFL odds page.

NFL Week 3 betting promos and codes

Make the most of Dimers' Steelers vs. Patriots predictions by exploring the two exciting offers below.

DraftKings Sportsbook

Sign up for DraftKings Sportsbook! Bet $5, get $200 in bonus bets instantly plus over $200 off NFL Sunday Ticket.

Bet365 Sportsbook

Join Bet365 Sportsbook! Bet $5, get $200 in bonus bets win or lose.

Conclusion

We predict the Patriots, with a 55% win probability, will likely beat the Steelers in Week 3 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Steelers vs. Patriots matchup, with human oversight maintaining high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee.

More on NFL

Stay up-to-date with the latest NFL betting news and data-driven parlay picks all season long. Plus, our Super Bowl odds for top predictions and the best available odds on the Super Bowl, AFC, NFC and each division.