Pirates vs. Nationals prediction: Why Washington is favored to win Saturday's MLB matchup [9/13/2025]

The Washington Nationals and Pittsburgh Pirates will meet in MLB action at Nationals Park on Saturday, starting at 4:05PM ET.

The Nationals will have Andrew Alvarez (1-0, 1.86 ERA) as their starting pitcher, pitting him against Bubba Chandler (2-1, 7.36 ERA) for the Pirates.

Based on the latest simulation results, Dimers' advanced MLB model predicts the Nationals as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including best bets and picks, visit our interactive Pirates vs. Nationals predictions page.

Nationals vs. Pirates prediction: Who will win, cover the run line?

Using powerful machine learning and data analysis, we have simulated the result of Saturday's MLB matchup between the Pirates and Nationals 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Nationals a 51% chance of beating the Pirates.

According to our model, the Nationals (+1.5) have a 63% chance of covering the run line, while the 9-run over/under has an equal 50-50 chance of hitting.

Pirates vs. Nationals odds [9/13/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Pirates	Nationals
Run Line	-1.5 (+150)	+1.5 (-166)
Moneyline	-110	-102
Total	o9 (-117)	u9 (+100)

All odds are correct at the time of publication and are subject to change.

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Pirates vs. Nationals picks and best bets

Our model's strongest edge in today's Pirates vs. Nationals matchup is on the over/under.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free ⚾️ picks

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Pirates vs. Nationals game-day updates and essential details

Saturday's MLB game between the Nationals and Pirates at Nationals Park is scheduled to begin at 4:05PM ET.

• Who: Pittsburgh Pirates vs. Washington Nationals
• Date: Saturday, September 13, 2025
• Time: 4:05PM ET/1:05PM PT
• Venue: Nationals Park

Dimers' in-depth preview of Saturday's Pirates vs. Nationals matchup includes our prediction, picks and the latest betting odds.

Before making any Pirates vs. Nationals picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Nationals, with a 51% win probability, will likely beat the Pirates on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Pirates vs. Nationals insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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