Pirates vs. Nationals prediction: Why Washington is favored to win Friday's MLB matchup [9/12/2025]

The Washington Nationals and Pittsburgh Pirates will meet in MLB action at Nationals Park on Friday, starting at 6:45PM ET.

The Nationals will have Brad Lord (5-8, 4.20 ERA) as their starting pitcher, while the Pirates will counter with Mitch Keller (6-14, 4.16 ERA).

Based on the latest simulation results, Dimers' proven MLB model predicts the Nationals as the most likely winner of today's game.

For a closer look at Friday's matchup, including best bets and picks, visit our interactive Pirates vs. Nationals predictions page.

Nationals vs. Pirates prediction: Who will win?

Using trusted machine learning and data analysis, we have simulated the result of Friday's MLB game between the Pirates and Nationals 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Nationals a 52% chance of beating the Pirates.

According to our model, the 8.5-run over/under also has an equal 50-50 chance of hitting.

Pirates vs. Nationals odds [9/12/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Pirates	Nationals
Moneyline	-106	-107
Total	o8.5 (-106)	u8.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Pirates vs. Nationals picks and best bets

Our model's biggest edge in today's Pirates vs. Nationals matchup is on the moneyline.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

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Pirates vs. Nationals game-day updates and essential details

Friday's MLB matchup between the Nationals and Pirates at Nationals Park is scheduled to begin at 6:45PM ET.

• Who: Pittsburgh Pirates vs. Washington Nationals
• Date: Friday, September 12, 2025
• Time: 6:45PM ET/3:45PM PT
• Venue: Nationals Park

Dimers' full preview of Friday's Pirates vs. Nationals matchup includes our prediction, picks and the latest betting odds.

Before making any Pirates vs. Nationals picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Nationals, with a 52% win probability, will likely beat the Pirates on Friday.

AI and automation have enhanced this article to quickly deliver accurate Pirates vs. Nationals insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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