Pirates vs. Cardinals prediction: St. Louis favored to win Wednesday's MLB matchup [8/27/2025]

MLB action continues on Wednesday at 7:45PM ET as the Pittsburgh Pirates take on the St. Louis Cardinals at Busch Stadium.

The Cardinals will send Sonny Gray (12-6, 4.34 ERA) to the mound, while the Pirates are going with Carmen Mlodzinski (3-7, 3.89 ERA).

Based on updated simulation results, Dimers' proven MLB model predicts the Cardinals as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Pirates-Cardinals game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Cardinals' chance of winning at 61%, with the Pirates at 39%."

For a closer look at Wednesday's matchup, including best bets and picks, visit our interactive Pirates vs. Cardinals predictions page.

Cardinals vs. Pirates prediction: Who will win, cover the run line?

Using trusted machine learning and data, we have simulated the result of Wednesday's MLB game between the Pirates and Cardinals 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Cardinals a 61% chance of defeating the Pirates.

According to our model, the Pirates (+1.5) have a 59% chance of covering the run line, while the 7.5-run over/under has an equal 50-50 chance of hitting.

Pirates vs. Cardinals odds [8/27/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Pirates	Cardinals
Run Line	+1.5 (-146)	-1.5 (+125)
Moneyline	+146	-174
Total	o7.5 (+102)	u7.5 (-120)

All odds are correct at the time of publication and are subject to change.

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Pirates vs. Cardinals picks and best bets

Our model's biggest edge in today's Pirates vs. Cardinals matchup is on the run line.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets

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Pirates vs. Cardinals game-day updates and essential details

Wednesday's MLB matchup between the Cardinals and Pirates at Busch Stadium is scheduled to start at 7:45PM ET.

• Who: Pittsburgh Pirates vs. St. Louis Cardinals
• Date: Wednesday, August 27, 2025
• Time: 7:45PM ET/4:45PM PT
• Venue: Busch Stadium

Dimers.com's full preview of Wednesday's Pirates vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

Before making any Pirates vs. Cardinals picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Cardinals, with a 61% win probability, will likely beat the Pirates on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Pirates vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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