Pirates vs. Cardinals Prediction: Pittsburgh Predicted to Win Tuesday's MLB Matchup [5/6/2025]

The St. Louis Cardinals will face the Pittsburgh Pirates in MLB action at Busch Stadium on Tuesday, beginning at 7:45PM ET.

The Cardinals will have Matthew Liberatore (2-3, 3.44 ERA) as their starting pitcher, while the Pirates have opted for Paul Skenes (3-3, 2.74 ERA).

Based on the latest simulation results, Dimers' proven MLB model (see Dimers Pro for full access) projects the Pirates as the most likely winner of today's game.

"Our team has analyzed the latest data and conducted 10,000 simulations for Tuesday's Pittsburgh-St. Louis game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various factors, our prediction shows the Pirates with a win probability of 52%, compared to 48% for the Cardinals."

For expanded analysis of Tuesday's matchup, including best bets and picks, visit our interactive Pirates vs. Cardinals predictions page.

Cardinals vs. Pirates Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data, we have simulated the result of Tuesday's MLB game between the Pirates and Cardinals 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Pirates a 52% chance of defeating the Cardinals.

According to our model, the Cardinals (+1.5) have a 63% chance of covering the run line, while the 7-run over/under has an equal 50-50 chance of hitting.

Pirates vs. Cardinals Odds [5/6/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Pirates	Cardinals
Run Line	-1.5 (+150)	+1.5 (-175)
Moneyline	-118	+100
Total	o7 (-115)	u7 (-102)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Pirates vs. Cardinals Picks and Best Bets

Our model's strongest edge in today's Pirates vs. Cardinals matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Video

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Pirates vs. Cardinals Game-Day Updates and Essential Details

Tuesday's MLB game between the Cardinals and Pirates at Busch Stadium is scheduled to commence at 7:45PM ET.

• Who: Pittsburgh Pirates vs. St. Louis Cardinals
• Date: Tuesday, May 6, 2025
• Time: 7:45PM ET/4:45PM PT
• Venue: Busch Stadium

Dimers.com's full preview of Tuesday's Pirates vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

Before making any Pittsburgh vs. St. Louis picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
• Understand where sports odds come from and how they're applied to baseball matchups
• Learn how to use Dimers Futures to find long-term betting opportunities as the World Series draws closer
• Stay informed with where online sports betting is currently legal and which betting sites are safest to use
• Boost your success with strategies to win at sports betting and explore why MLB is one of the best leagues to bet on

Conclusion

We predict the Pirates, with a 52% win probability, will likely beat the Cardinals on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Pirates vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Stay informed with the latest MLB news and MLB parlay picks throughout the season. Plus, our World Series odds offer the latest predictions for the World Series, American League, National League and each division.