Pirates vs. Cardinals prediction: St. Louis favored to win Tuesday's MLB matchup [8/26/2025]

The St. Louis Cardinals and Pittsburgh Pirates will meet in MLB action at Busch Stadium on Tuesday, starting at 7:45PM ET.

Andre Pallante (6-11, 5.17 ERA) will start for the Cardinals, while the Pirates have opted for Mitch Keller (5-12, 4.34 ERA).

Based on the latest simulations, Dimers' advanced MLB model predicts the Cardinals as the most likely winner of today's game.

For further insights into Tuesday's matchup, including best bets and picks, visit our interactive Pirates vs. Cardinals predictions page.

Cardinals vs. Pirates prediction: Who will win, cover the run line?

Using innovative machine learning and data, we have simulated the outcome of Tuesday's MLB matchup between the Pirates and Cardinals 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Cardinals a 54% chance of beating the Pirates.

According to our model, the Pirates (+1.5) have a 64% chance of covering the run line, while the over/under total of 8 runs has a 53% chance of going over.

Pirates vs. Cardinals odds [8/26/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Pirates	Cardinals
Run Line	+1.5 (-200)	-1.5 (+168)
Moneyline	+108	-125
Total	o8 (-110)	u8 (-106)

All odds are correct at the time of publication and are subject to change.

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Pirates vs. Cardinals picks and best bets

Our model's biggest edge in today's Pirates vs. Cardinals matchup is on the run line.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Pirates vs. Cardinals game-day updates and essential details

Tuesday's MLB game between the Cardinals and Pirates at Busch Stadium is scheduled to begin at 7:45PM ET.

• Who: Pittsburgh Pirates vs. St. Louis Cardinals
• Date: Tuesday, August 26, 2025
• Time: 7:45PM ET/4:45PM PT
• Venue: Busch Stadium

Dimers.com's in-depth preview of Tuesday's Pirates vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

Before making any Pirates vs. Cardinals picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Cardinals, with a 54% win probability, will likely beat the Pirates on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Pirates vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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