Pirates vs. Cardinals prediction: St. Louis favored to win Thursday's MLB matchup [8/28/2025]

The St. Louis Cardinals and Pittsburgh Pirates are scheduled to meet in MLB action at Busch Stadium on Thursday, starting at 2:15PM ET.

Miles Mikolas (6-10, 5.17 ERA) will be the starting pitcher for the Cardinals, while the Pirates have opted for Braxton Ashcraft (4-2, 2.70 ERA).

Based on the latest simulations, Dimers' advanced MLB model predicts the Cardinals as the most likely winner of today's game.

For further insights into Thursday's matchup, including best bets and picks, visit our interactive Pirates vs. Cardinals predictions page.

Cardinals vs. Pirates prediction: Who will win, cover the run line?

Using powerful machine learning and data, we have simulated the outcome of Thursday's MLB game between the Pirates and Cardinals 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Cardinals a 52% chance of defeating the Pirates.

According to our model, the Pirates (+1.5) have a 65% chance of covering the run line, while the over/under total of 8 runs has a 54% chance of going over.

Pirates vs. Cardinals odds [8/28/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Pirates	Cardinals
Run Line	+1.5 (-201)	-1.5 (+163)
Moneyline	+104	-120
Total	o8 (-113)	u8 (+100)

All odds are correct at the time of publication and are subject to change.

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Pirates vs. Cardinals picks and best bets

Our model's strongest edge in today's Pirates vs. Cardinals matchup is on the run line.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Pirates vs. Cardinals game-day updates and essential details

Thursday's MLB matchup between the Cardinals and Pirates at Busch Stadium is scheduled to start at 2:15PM ET.

• Who: Pittsburgh Pirates vs. St. Louis Cardinals
• Date: Thursday, August 28, 2025
• Time: 2:15PM ET/11:15AM PT
• Venue: Busch Stadium

Dimers.com's full preview of Thursday's Pirates vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

Before making any Pirates vs. Cardinals picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Cardinals, with a 52% win probability, will likely beat the Pirates on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Pirates vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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