Pirates vs. Cardinals Prediction: St. Louis Predicted to Win Monday's MLB Matchup [5/5/2025]

The St. Louis Cardinals will face the Pittsburgh Pirates in MLB action at Busch Stadium on Monday, commencing at 7:45PM ET.

The Cardinals will send Miles Mikolas (1-2, 4.66 ERA) to the mound, while the Pirates have opted for Carmen Mlodzinski (1-3, 6.58 ERA).

Based on the latest simulations, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Cardinals as the most likely winner of today's game.

"Our team has utilized the latest data to simulate Monday's Pittsburgh-St. Louis game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Incorporating recent updates and thousands of additional inputs, our prediction shows the Cardinals are likely to win, with a probability of 56%, compared to the Pirates' 44%."

For a closer look at Monday's matchup, including best bets and picks, visit our interactive Pirates vs. Cardinals predictions page.

Cardinals vs. Pirates Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and statistical analysis, we have simulated the outcome of Monday's MLB game between the Pirates and Cardinals 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Cardinals a 56% chance of beating the Pirates.

According to our model, the Pirates (+1.5) have a 63% chance of covering the run line, while the over/under total of 8.5 runs has a 53% chance of staying under.

Pirates vs. Cardinals Odds [5/5/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Pirates	Cardinals
Run Line	+1.5 (-180)	-1.5 (+160)
Moneyline	+114	-130
Total	o8.5 (-102)	u8.5 (-118)

All odds are correct at the time of publication and are subject to change.

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Pirates vs. Cardinals Picks and Best Bets

Our model's biggest edge in today's Pirates vs. Cardinals matchup is on the moneyline.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Pirates vs. Cardinals Game-Day Updates and Essential Details

Monday's MLB game between the Cardinals and Pirates at Busch Stadium is scheduled to begin at 7:45PM ET.

• Who: Pittsburgh Pirates vs. St. Louis Cardinals
• Date: Monday, May 5, 2025
• Time: 7:45PM ET/4:45PM PT
• Venue: Busch Stadium

Dimers.com's full preview of Monday's Pirates vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

Before making any Pittsburgh vs. St. Louis picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Cardinals, with a 56% win probability, will likely beat the Pirates on Monday.

AI and automation have enhanced this article to quickly deliver accurate Pirates vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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