Pirates vs. Cardinals prediction: St. Louis favored to win Monday's MLB matchup [8/25/2025]

The St. Louis Cardinals and Pittsburgh Pirates will meet in MLB action at Busch Stadium on Monday, starting at 7:45PM ET.

Michael McGreevy (5-2, 4.26 ERA) will be the starting pitcher for the Cardinals, pitting him against Johan Oviedo (1-0, 4.50 ERA) for the Pirates.

Based on the latest simulation results, Dimers' advanced MLB model predicts the Cardinals as the most likely winner of today's game.

For further insights into Monday's matchup, including best bets and picks, visit our interactive Pirates vs. Cardinals predictions page.

Cardinals vs. Pirates prediction: Who will win, cover the run line?

Using trusted machine learning and data, we have simulated the outcome of Monday's MLB game between the Pirates and Cardinals 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Cardinals a 56% chance of beating the Pirates.

According to our model, the Pirates (+1.5) have a 64% chance of covering the run line, while the 7.5-run over/under has a 53% chance of going over.

Pirates vs. Cardinals odds [8/25/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Pirates	Cardinals
Run Line	+1.5 (-188)	-1.5 (+165)
Moneyline	+117	-130
Total	o7.5 (-120)	u7.5 (-102)

All odds are correct at the time of publication and are subject to change.

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Pirates vs. Cardinals picks and best bets

Our model's biggest edge in today's Pirates vs. Cardinals matchup is on the moneyline.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

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Pirates vs. Cardinals game-day updates and essential details

Monday's MLB game between the Cardinals and Pirates at Busch Stadium is scheduled to begin at 7:45PM ET.

• Who: Pittsburgh Pirates vs. St. Louis Cardinals
• Date: Monday, August 25, 2025
• Time: 7:45PM ET/4:45PM PT
• Venue: Busch Stadium

Dimers.com's full preview of Monday's Pirates vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

Before making any Pirates vs. Cardinals picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Plus, with Missouri sports betting set to launch on December 1, 2025, Dimers is your trusted source for the latest updates and the best MO sports betting promos.

Conclusion

We predict the Cardinals, with a 56% win probability, will likely beat the Pirates on Monday.

AI and automation have enhanced this article to quickly deliver accurate Pirates vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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