Pirates vs. Padres Prediction: San Diego Predicted to Win Saturday's MLB Matchup [5/31/2025]

The San Diego Padres will take on the Pittsburgh Pirates in MLB action at PETCO Park on Saturday, commencing at 9:40PM ET.

The Padres will have Dylan Cease (1-3, 4.58 ERA) as their starting pitcher, while the Pirates have opted for Bailey Falter (3-3, 3.47 ERA).

Based on updated simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Padres as the most likely winner of today's game.

"Our team has used the latest data to run 10,000 simulations of Saturday's Pittsburgh-San Diego game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various other inputs, we estimate that the Padres are more likely to win, while the Pirates have a lower chance of victory."

For further insights into Saturday's matchup, including best bets and picks, visit our interactive Pirates vs. Padres predictions page.

Padres vs. Pirates Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data, we have simulated the result of Saturday's MLB game between the Pirates and Padres 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Padres a 67% chance of defeating the Pirates.

According to our model, the Pirates (+1.5) have a 52% chance of covering the run line, while the over/under total of 7.5 runs has an equal 50-50 chance of hitting.

Pirates vs. Padres Odds [5/31/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Pirates	Padres
Run Line	+1.5 (-108)	-1.5 (-105)
Moneyline	+198	-220
Total	o7.5 (-112)	u7.5 (+102)

All odds are correct at the time of publication and are subject to change.

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Pirates vs. Padres Picks and Best Bets

Our model's strongest edge in today's Pirates vs. Padres matchup is on the over/under.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Pirates vs. Padres Game-Day Updates and Essential Details

Saturday's MLB game between the Padres and Pirates at PETCO Park is scheduled to begin at 9:40PM ET.

• Who: Pittsburgh Pirates vs. San Diego Padres
• Date: Saturday, May 31, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: PETCO Park

Dimers.com's in-depth preview of Saturday's Pirates vs. Padres matchup includes our prediction, picks and the latest betting odds.

Before making any Pittsburgh vs. San Diego picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Padres, with a 67% win probability, will likely beat the Pirates on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Pirates vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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