Pirates vs. Padres Prediction: San Diego Predicted to Win Friday's MLB Matchup [5/30/2025]

The San Diego Padres and Pittsburgh Pirates will meet in MLB action at PETCO Park on Friday, starting at 9:40PM ET.

The Padres will send Nick Pivetta (5-2, 2.72 ERA) to the mound, pitting him against Mitch Keller (1-6, 3.66 ERA) for the Pirates.

Based on updated simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Padres as the most likely winner of today's game.

"Employing the latest data, our experts simulated Friday's Pittsburgh-San Diego game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"After computing the latest updates and thousands of other inputs, we predict the Padres' chance of winning is 64%, while the Pirates' is 36%."

For further insights into Friday's matchup, including best bets and picks, visit our interactive Pirates vs. Padres predictions page.

Padres vs. Pirates Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and statistical analysis, we have simulated the result of Friday's MLB matchup between the Pirates and Padres 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Padres a 64% chance of beating the Pirates.

According to our model, the Pirates (+1.5) have a 56% chance of covering the run line, while the 7.5-run over/under has a 52% chance of staying under.

Pirates vs. Padres Odds [5/30/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Pirates	Padres
Run Line	+1.5 (-145)	-1.5 (+120)
Moneyline	+155	-188
Total	o7.5 (+100)	u7.5 (-120)

All odds are correct at the time of publication and are subject to change.

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Pirates vs. Padres Picks and Best Bets

Our model's biggest edge in today's Pirates vs. Padres matchup is on the moneyline.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Video

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Pirates vs. Padres Game-Day Updates and Essential Details

Friday's MLB action between the Padres and Pirates at PETCO Park is scheduled to commence at 9:40PM ET.

• Who: Pittsburgh Pirates vs. San Diego Padres
• Date: Friday, May 30, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: PETCO Park

Dimers.com's comprehensive preview of Friday's Pirates vs. Padres matchup includes our prediction, picks and the latest betting odds.

Before making any Pittsburgh vs. San Diego picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Padres, with a 64% win probability, will likely beat the Pirates on Friday.

AI and automation have enhanced this article to quickly deliver accurate Pirates vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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