Pirates vs. Phillies Prediction: Philadelphia Predicted to Win Friday's MLB Matchup [5/16/2025]

The Philadelphia Phillies will take on the Pittsburgh Pirates in MLB action at Citizens Bank Park on Friday, starting at 6:45PM ET.

The Phillies will have Ranger Suárez (1-0, 5.91 ERA) as their starting pitcher, while the Pirates have opted for Andrew Heaney (2-3, 3.15 ERA).

Based on updated simulations, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Phillies as the most likely winner of today's game.

"Employing the latest data, our experts simulated Friday's Pittsburgh-Philadelphia game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"After computing the latest updates and thousands of other inputs, we predict the Phillies' chance of winning is 67%, while the Pirates' is 33%."

For further insights into Friday's matchup, including best bets and picks, visit our interactive Pirates vs. Phillies predictions page.

Phillies vs. Pirates Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data, we have simulated the result of Friday's MLB matchup between the Pirates and Phillies 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Phillies a 67% chance of beating the Pirates.

According to our model, the Pirates (+1.5) have a 51% chance of covering the run line, while the over/under total of 9 runs has a 55% chance of staying under.

Pirates vs. Phillies Odds [5/16/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Pirates	Phillies
Run Line	+1.5 (+105)	-1.5 (-120)
Moneyline	+200	-230
Total	o9 (-110)	u9 (+100)

All odds are correct at the time of publication and are subject to change.

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Pirates vs. Phillies Picks and Best Bets

Our model's strongest edge in today's Pirates vs. Phillies matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free MLB Picks

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Pirates vs. Phillies Game-Day Updates and Essential Details

Friday's MLB game between the Phillies and Pirates at Citizens Bank Park is scheduled to commence at 6:45PM ET.

• Who: Pittsburgh Pirates vs. Philadelphia Phillies
• Date: Friday, May 16, 2025
• Time: 6:45PM ET/3:45PM PT
• Venue: Citizens Bank Park

Dimers.com's comprehensive preview of Friday's Pirates vs. Phillies matchup includes our prediction, picks and the latest betting odds.

Before making any Pittsburgh vs. Philadelphia picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Phillies, with a 67% win probability, will likely beat the Pirates on Friday.

AI and automation have enhanced this article to quickly deliver accurate Pirates vs. Phillies insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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