Pirates vs. Brewers Prediction: Milwaukee Predicted to Win Wednesday's MLB Matchup [6/25/2025]

MLB action continues on Wednesday at 2:10PM ET as the Pittsburgh Pirates square off with the Milwaukee Brewers at American Family Field.

Jacob Misiorowski (2-0, 1.64 ERA) will be on the bump for the Brewers, while the Pirates are going with Paul Skenes (4-6, 1.85 ERA).

Based on updated simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Brewers as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Pirates-Brewers game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Brewers' chance of winning at 51%, with the Pirates at 49%."

For further insights into Wednesday's matchup, including best bets and picks, visit our interactive Pirates vs. Brewers predictions page.

Brewers vs. Pirates Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data, we have simulated the outcome of Wednesday's MLB game between the Pirates and Brewers 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Brewers a 51% chance of defeating the Pirates.

According to our model, the Brewers (+1.5) have a 66% chance of covering the run line, while the over/under total of 6.5 runs has a 51% chance of going over.

Pirates vs. Brewers Odds [6/25/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Pirates	Brewers
Run Line	-1.5 (+165)	+1.5 (-195)
Moneyline	-108	-108
Total	o6.5 (-103)	u6.5 (-102)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Pirates vs. Brewers Picks and Best Bets

Our model's strongest edge in today's Pirates vs. Brewers matchup is on the run line.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the free picks featured below.

Pirates vs. Brewers Game-Day Updates and Essential Details

Wednesday's MLB matchup between the Brewers and Pirates at American Family Field is scheduled to begin at 2:10PM ET.

• Who: Pittsburgh Pirates vs. Milwaukee Brewers
• Date: Wednesday, June 25, 2025
• Time: 2:10PM ET/11:10AM PT
• Venue: American Family Field

Dimers.com's full preview of Wednesday's Pirates vs. Brewers matchup includes our prediction, picks and the latest betting odds.

Before making any Pirates vs. Brewers picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
• Understand where sports odds come from and how they're applied to baseball matchups
• Learn how to use Dimers Futures to find long-term betting opportunities as the World Series draws closer
• Stay informed with where online sports betting is currently legal and which betting sites are safest to use
• Boost your success with strategies to win at sports betting and explore why MLB is one of the best leagues to bet on

Conclusion

We predict the Brewers, with a 51% win probability, will likely beat the Pirates on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Pirates vs. Brewers insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Keep up with the latest MLB news and MLB parlay picks throughout the season. Plus, our World Series odds offer the latest probabilities for the World Series, American League, National League and each division.