Pirates vs. Angels Prediction: Angels Predicted to Win Tuesday's MLB Matchup [4/22/2025]

The Los Angeles Angels and Pittsburgh Pirates will meet in MLB action at Angel Stadium on Tuesday, starting at 9:38PM ET.

José Soriano (2-2, 3.16 ERA) will be the starting pitcher for the Angels, up against Bailey Falter (1-2, 4.91 ERA) for the Pirates.

Based on the latest simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Angels as the most likely winner of today's game.

"Our team has analyzed the latest data and conducted 10,000 simulations for Tuesday's Pittsburgh-LA Angels game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various factors, our prediction shows the Angels with a win probability of 64%, compared to 36% for the Pirates."

For expanded analysis of Tuesday's matchup, including best bets and picks, visit our interactive Pirates vs. Angels predictions page.

Angels vs. Pirates Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and statistical analysis, we have simulated the outcome of Tuesday's MLB game between the Pirates and Angels 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Angels a 64% chance of beating the Pirates.

According to our model, the Pirates (+1.5) have a 54% chance of covering the run line, while the 8.5-run over/under has a 51% chance of staying under.

Pirates vs. Angels Odds [4/22/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Pirates	Angels
Run Line	+1.5 (-130)	-1.5 (+116)
Moneyline	+155	-180
Total	o8.5 (-115)	u8.5 (+102)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Pirates vs. Angels Picks and Best Bets

Our model's strongest edge in today's Pirates vs. Angels matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Pirates vs. Angels Game-Day Updates and Essential Details

Tuesday's MLB game between the Angels and Pirates at Angel Stadium is scheduled to begin at 9:38PM ET.

• Who: Pittsburgh Pirates vs. Los Angeles Angels
• Date: Tuesday, April 22, 2025
• Time: 9:38PM ET/6:38PM PT
• Venue: Angel Stadium

Dimers.com's in-depth preview of Tuesday's Pirates vs. Angels matchup includes our prediction, picks and the latest betting odds.

Before making any Pittsburgh vs. LA Angels picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
• Understand where sports odds come from and how they're applied to baseball matchups
• Learn how to use Dimers Futures to find long-term betting opportunities as the World Series draws closer
• Stay informed with where online sports betting is currently legal and which betting sites are safest to use
• Boost your success with strategies to win at sports betting and explore why MLB is one of the best leagues to bet on

Conclusion

We predict the Angels, with a 64% win probability, will likely beat the Pirates on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Pirates vs. Angels insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Stay informed with the latest MLB betting news and MLB parlay picks throughout the season. Plus, our World Series odds provide the most up-to-date probabilities for the World Series, American League, National League and each division.