Pirates vs. Reds prediction: Cy Young candidate Paul Skenes takes on Cincinnati tonight [9/24/2025]

The Cincinnati Reds will take on the Pittsburgh Pirates in MLB action at Great American Ball Park on Wednesday, commencing at 6:40PM ET.

Hunter Greene (7-4, 2.74 ERA) will be on the bump for the Reds, while the Pirates have opted for Cy Young hopeful Paul Skenes (10-10, 2.03 ERA).

Based on the latest simulation results, Dimers' proven MLB model predicts the Reds as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Pirates-Reds game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Reds' chance of winning at 53%, with the Pirates at 47%."

For a closer look at Wednesday's matchup, including best bets and picks, visit our interactive Pirates vs. Reds predictions page.

Reds vs. Pirates prediction: Who will win, cover the run line?

Using trusted machine learning and data analysis, we have simulated the outcome of Wednesday's MLB game between the Pirates and Reds 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Reds a 53% chance of defeating the Pirates.

According to our model, the Pirates (+1.5) have a 66% chance of covering the run line, while the over/under total of 7 runs has a 55% chance of going over.

Pirates vs. Reds odds [9/24/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Pirates	Reds
Run Line	+1.5 (-218)	-1.5 (+176)
Moneyline	+108	-122
Total	o7 (-104)	u7 (-111)

All odds are correct at the time of publication and are subject to change.

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Pirates vs. Reds picks and best bets

Our model's strongest edge in today's Pirates vs. Reds matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

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Pirates vs. Reds game-day updates and essential details

Wednesday's MLB action between the Reds and Pirates at Great American Ball Park is scheduled to commence at 6:40PM ET.

• Who: Pittsburgh Pirates vs. Cincinnati Reds
• Date: Wednesday, September 24, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: Great American Ball Park

Dimers' comprehensive preview of Wednesday's Pirates vs. Reds matchup includes our prediction, picks and the latest betting odds.

Before making any Pirates vs. Reds picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Reds, with a 53% win probability, will likely beat the Pirates on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Pirates vs. Reds insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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