Pirates vs. Reds prediction: Why Cincinnati is favored to win Tuesday's MLB matchup [9/23/2025]

The Cincinnati Reds and Pittsburgh Pirates will lock horns in MLB action at Great American Ball Park on Tuesday, starting at 6:40PM ET.

Brady Singer (14-10, 3.86 ERA) will start on the mound for the Reds, while the Pirates have opted for Johan Oviedo (2-0, 3.52 ERA).

Based on the latest simulation results, Dimers' advanced MLB model predicts the Reds as the most likely winner of today's game.

For further insights into Tuesday's matchup, including best bets and picks, visit our interactive Pirates vs. Reds predictions page.

Reds vs. Pirates prediction: Who will win, cover the run line?

Using trusted machine learning and statistical analysis, we have simulated the result of Tuesday's MLB matchup between the Pirates and Reds 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Reds a 59% chance of defeating the Pirates.

According to our model, the Pirates (+1.5) have a 60% chance of covering the run line, while the over/under total of 8 runs has a 54% chance of going over.

Pirates vs. Reds odds [9/23/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Pirates	Reds
Run Line	+1.5 (-145)	-1.5 (+125)
Moneyline	+150	-172
Total	o8 (-104)	u8 (-108)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Pirates vs. Reds picks and best bets

Our model's biggest edge in today's Pirates vs. Reds matchup is on the run line.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Pirates vs. Reds game-day updates and essential details

Tuesday's MLB matchup between the Reds and Pirates at Great American Ball Park is scheduled to start at 6:40PM ET.

• Who: Pittsburgh Pirates vs. Cincinnati Reds
• Date: Tuesday, September 23, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: Great American Ball Park

Dimers' comprehensive preview of Tuesday's Pirates vs. Reds matchup includes our prediction, picks and the latest betting odds.

Before making any Pirates vs. Reds picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Reds, with a 59% win probability, will likely beat the Pirates on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Pirates vs. Reds insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Stay up-to-date with the latest MLB betting news and MLB parlay picks throughout the season. Plus, our World Series odds offer the latest probabilities for the World Series, American League, National League and each division.