Pirates vs. Reds prediction: Why Cincinnati is favored to win Thursday's MLB matchup [9/25/2025]

The Cincinnati Reds will face the Pittsburgh Pirates in MLB action at Great American Ball Park on Thursday, commencing at 12:40PM ET.

Nick Lodolo (8-8, 3.44 ERA) will start on the mound for the Reds, up against Braxton Ashcraft (4-3, 2.62 ERA) for the Pirates.

Based on the latest simulations, Dimers' proven MLB model predicts the Reds as the most likely winner of today's game.

For a closer look at Thursday's matchup, including best bets and picks, visit our interactive Pirates vs. Reds predictions page.

Reds vs. Pirates prediction: Who will win, cover the run line?

Using trusted machine learning and statistical analysis, we have simulated the outcome of Thursday's MLB matchup between the Pirates and Reds 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Reds a 59% chance of beating the Pirates.

According to our model, the Pirates (+1.5) have a 59% chance of covering the run line, while the 7.5-run over/under has a 56% chance of going over.

Pirates vs. Reds odds [9/25/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Pirates	Reds
Run Line	+1.5 (-154)	-1.5 (+135)
Moneyline	+144	-170
Total	o7.5 (-110)	u7.5 (-102)

All odds are correct at the time of publication and are subject to change.

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Pirates vs. Reds picks and best bets

Our model's biggest edge in today's Pirates vs. Reds matchup is on the run line.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

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Pirates vs. Reds game-day updates and essential details

Thursday's MLB action between the Reds and Pirates at Great American Ball Park is scheduled to begin at 12:40PM ET.

• Who: Pittsburgh Pirates vs. Cincinnati Reds
• Date: Thursday, September 25, 2025
• Time: 12:40PM ET/9:40AM PT
• Venue: Great American Ball Park

Dimers' in-depth preview of Thursday's Pirates vs. Reds matchup includes our prediction, picks and the latest betting odds.

Before making any Pirates vs. Reds picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Reds, with a 59% win probability, will likely beat the Pirates on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Pirates vs. Reds insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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