Pirates vs. Cubs prediction: Cubs predicted to win Saturday's MLB matchup [8/16/2025]

MLB action continues on Saturday at 2:20PM ET as the Pittsburgh Pirates take on the favored Chicago Cubs at Wrigley Field.

Shota Imanaga (8-5, 3.19 ERA) will get the ball for the Cubs, while the Pirates are going with Mike Burrows (1-4, 4.66 ERA).

Based on updated simulations, Dimers' advanced MLB model projects the Cubs as the most likely winner of today's game.

For further insights into Saturday's matchup, including best bets and picks, visit our interactive Pirates vs. Cubs predictions page.

Cubs vs. Pirates prediction: Who will win, cover the run line?

Using innovative machine learning and data analysis, we have simulated the outcome of Saturday's MLB matchup between the Pirates and Cubs 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Cubs a 66% chance of defeating the Pirates.

According to our model, the Pirates (+1.5) have a 52% chance of covering the run line, while the over/under total of 8.5 runs has a 52% chance of staying under.

Pirates vs. Cubs odds [8/16/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Pirates	Cubs
Run Line	+1.5 (-110)	-1.5 (-110)
Moneyline	+180	-220
Total	o8.5 (-118)	u8.5 (+100)

All odds are correct at the time of publication and are subject to change.

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Pirates vs. Cubs picks and best bets

Our model's biggest edge in today's Pirates vs. Cubs matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free ⚾️ picks

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Pirates vs. Cubs game-day updates and essential details

Saturday's MLB game between the Cubs and Pirates at Wrigley Field is scheduled to start at 2:20PM ET.

• Who: Pittsburgh Pirates vs. Chicago Cubs
• Date: Saturday, August 16, 2025
• Time: 2:20PM ET/11:20AM PT
• Venue: Wrigley Field

Dimers.com's in-depth preview of Saturday's Pirates vs. Cubs matchup includes our prediction, picks and the latest betting odds.

Before making any Pirates vs. Cubs picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Cubs, with a 66% win probability, will likely beat the Pirates on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Pirates vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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