Pirates vs. Cubs prediction: Cubs predicted to win Friday's MLB matchup [8/15/2025]

The Chicago Cubs will face the Pittsburgh Pirates in MLB action at Wrigley Field on Friday, starting at 2:20PM ET.

The Cubs will send Colin Rea (9-5, 4.09 ERA) to the mound, while the Pirates have opted for Braxton Ashcraft (3-2, 3.19 ERA).

Based on the latest simulation results, Dimers' proven MLB model projects the Cubs as the most likely winner of today's game.

For expanded analysis of Friday's matchup, including best bets and picks, visit our interactive Pirates vs. Cubs predictions page.

Cubs vs. Pirates prediction: Who will win, cover the run line?

Using trusted machine learning and data, we have simulated the result of Friday's MLB matchup between the Pirates and Cubs 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Cubs a 64% chance of beating the Pirates.

According to our model, the Pirates (+1.5) have a 55% chance of covering the run line, while the over/under total of 8.5 runs has a 52% chance of going over.

Pirates vs. Cubs odds [8/15/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Pirates	Cubs
Run Line	+1.5 (-125)	-1.5 (+105)
Moneyline	+162	-190
Total	o8.5 (-115)	u8.5 (-104)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Pirates vs. Cubs picks and best bets

Our model's strongest edge in today's Pirates vs. Cubs matchup is on the over/under.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Pirates vs. Cubs game-day updates and essential details

Friday's MLB matchup between the Cubs and Pirates at Wrigley Field is scheduled to begin at 2:20PM ET.

• Who: Pittsburgh Pirates vs. Chicago Cubs
• Date: Friday, August 15, 2025
• Time: 2:20PM ET/11:20AM PT
• Venue: Wrigley Field

Dimers.com's full preview of Friday's Pirates vs. Cubs matchup includes our prediction, picks and the latest betting odds.

Before making any Pirates vs. Cubs picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Cubs, with a 64% win probability, will likely beat the Pirates on Friday.

AI and automation have enhanced this article to quickly deliver accurate Pirates vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Keep up with the latest MLB betting news and MLB parlay picks throughout the season. Plus, our World Series odds offer the latest projections for the World Series, American League, National League and each division.