Pirates vs. Orioles prediction: Pittsburgh favored to win Wednesday's MLB matchup [9/10/2025]

The Baltimore Orioles will face the Pittsburgh Pirates in MLB action at Oriole Park at Camden Yards on Wednesday, beginning at 6:35PM ET.

Tyler Wells (1-0, 3.60 ERA) will start for the Orioles, pitting him against Paul Skenes (10-9, 1.98 ERA) for the Pirates.

Based on updated simulations, Dimers' advanced MLB model predicts the Pirates as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Pirates-Orioles game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Pirates' chance of winning at 56%, with the Orioles at 44%."

For a closer look at Wednesday's matchup, including best bets and picks, visit our interactive Pirates vs. Orioles predictions page.

Orioles vs. Pirates prediction: Who will win, cover the run line?

Using powerful machine learning and data, we have simulated the result of Wednesday's MLB game between the Pirates and Orioles 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Pirates a 56% chance of defeating the Orioles.

According to our model, the Orioles (+1.5) have a 59% chance of covering the run line, while the over/under total of 7 runs has a 54% chance of going over.

Pirates vs. Orioles odds [9/10/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Pirates	Orioles
Run Line	-1.5 (+120)	+1.5 (-135)
Moneyline	-154	+135
Total	o7 (-104)	u7 (-114)

All odds are correct at the time of publication and are subject to change.

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Pirates vs. Orioles picks and best bets

Our model's strongest edge in today's Pirates vs. Orioles matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets today

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Pirates vs. Orioles game-day updates and essential details

Wednesday's MLB game between the Orioles and Pirates at Oriole Park at Camden Yards is scheduled to start at 6:35PM ET.

• Who: Pittsburgh Pirates vs. Baltimore Orioles
• Date: Wednesday, September 10, 2025
• Time: 6:35PM ET/3:35PM PT
• Venue: Oriole Park at Camden Yards

Dimers' in-depth preview of Wednesday's Pirates vs. Orioles matchup includes our prediction, picks and the latest betting odds.

Before making any Pirates vs. Orioles picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Pirates, with a 56% win probability, will likely beat the Orioles on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Pirates vs. Orioles insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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