Pirates vs. Orioles prediction: Baltimore favored to win Tuesday's MLB matchup [9/9/2025]

The Baltimore Orioles will take on the Pittsburgh Pirates in MLB action at Oriole Park at Camden Yards on Tuesday, commencing at 6:35PM ET.

The Orioles will send Kyle Bradish (0-1, 3.60 ERA) to the mound, while the Pirates have opted for Mike Burrows (2-4, 4.08 ERA).

Based on updated simulation results, Dimers' advanced MLB model predicts the Orioles as the most likely winner of today's game.

For expanded analysis of Tuesday's matchup, including best bets and picks, visit our interactive Pirates vs. Orioles predictions page.

Orioles vs. Pirates prediction: Who will win, cover the run line?

Using powerful machine learning and statistical analysis, we have simulated the result of Tuesday's MLB game between the Pirates and Orioles 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Orioles a 59% chance of defeating the Pirates.

According to our model, the Pirates (+1.5) have a 60% chance of covering the run line, while the 7.5-run over/under has a 54% chance of going over.

Pirates vs. Orioles odds [9/9/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Pirates	Orioles
Run Line	+1.5 (-170)	-1.5 (+146)
Moneyline	+127	-146
Total	o7.5 (-119)	u7.5 (+100)

All odds are correct at the time of publication and are subject to change.

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Pirates vs. Orioles picks and best bets

Our model's strongest edge in today's Pirates vs. Orioles matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets today

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Pirates vs. Orioles game-day updates and essential details

Tuesday's MLB game between the Orioles and Pirates at Oriole Park at Camden Yards is scheduled to start at 6:35PM ET.

• Who: Pittsburgh Pirates vs. Baltimore Orioles
• Date: Tuesday, September 9, 2025
• Time: 6:35PM ET/3:35PM PT
• Venue: Oriole Park at Camden Yards

Dimers' full preview of Tuesday's Pirates vs. Orioles matchup includes our prediction, picks and the latest betting odds.

Before making any Pirates vs. Orioles picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Orioles, with a 59% win probability, will likely beat the Pirates on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Pirates vs. Orioles insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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