Pirates vs. Orioles prediction: Baltimore favored to win Thursday's MLB matchup [9/11/2025]

The Baltimore Orioles will face the Pittsburgh Pirates in MLB action at Oriole Park at Camden Yards on Thursday, starting at 1:05PM ET.

The Orioles will have Cade Povich (3-7, 5.16 ERA) as their starting pitcher, pitting him against Johan Oviedo (2-0, 2.70 ERA) for the Pirates.

Based on the latest simulations, Dimers' proven MLB model predicts the Orioles as the most likely winner of today's game.

For a closer look at Thursday's matchup, including best bets and picks, visit our interactive Pirates vs. Orioles predictions page.

Orioles vs. Pirates prediction: Who will win, cover the run line?

Using trusted machine learning and data analysis, we have simulated the result of Thursday's MLB game between the Pirates and Orioles 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Orioles a 55% chance of beating the Pirates.

According to our model, the Pirates (+1.5) have a 63% chance of covering the run line, while the 8.5-run over/under has an equal 50-50 chance of hitting.

Pirates vs. Orioles odds [9/11/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Pirates	Orioles
Run Line	+1.5 (-220)	-1.5 (+165)
Moneyline	+108	-111
Total	o8.5 (+100)	u8.5 (-106)

All odds are correct at the time of publication and are subject to change.

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Pirates vs. Orioles picks and best bets

Our model's strongest edge in today's Pirates vs. Orioles matchup is on the moneyline.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

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Pirates vs. Orioles game-day updates and essential details

Thursday's MLB game between the Orioles and Pirates at Oriole Park at Camden Yards is scheduled to begin at 1:05PM ET.

• Who: Pittsburgh Pirates vs. Baltimore Orioles
• Date: Thursday, September 11, 2025
• Time: 1:05PM ET/10:05AM PT
• Venue: Oriole Park at Camden Yards

Dimers' comprehensive preview of Thursday's Pirates vs. Orioles matchup includes our prediction, picks and the latest betting odds.

Before making any Pirates vs. Orioles picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Orioles, with a 55% win probability, will likely beat the Pirates on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Pirates vs. Orioles insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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