Pirates vs. Diamondbacks Prediction: Arizona Predicted to Win Wednesday's MLB Matchup [5/28/2025]

The Arizona Diamondbacks will square off with the Pittsburgh Pirates in MLB action at Chase Field on Wednesday, starting at 3:40PM ET.

The Diamondbacks will have Zac Gallen (3-6, 5.25 ERA) as their starting pitcher, while the Pirates will counter with Paul Skenes (3-5, 2.36 ERA).

Based on the latest simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Diamondbacks as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Pittsburgh-Arizona game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Diamondbacks' chance of winning at 57%, with the Pirates at 43%."

For further insights into Wednesday's matchup, including best bets and picks, visit our interactive Pirates vs. Diamondbacks predictions page.

Diamondbacks vs. Pirates Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data, we have simulated the result of Wednesday's MLB game between the Pirates and Diamondbacks 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Diamondbacks a 57% chance of defeating the Pirates.

According to our model, the Pirates (+1.5) have a 64% chance of covering the run line, while the over/under total of 7.5 runs has an equal 50-50 chance of hitting.

Pirates vs. Diamondbacks Odds [5/28/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Pirates	Diamondbacks
Run Line	+1.5 (-192)	-1.5 (+170)
Moneyline	+120	-134
Total	o7.5 (-110)	u7.5 (-106)

All odds are correct at the time of publication and are subject to change.

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Pirates vs. Diamondbacks Picks and Best Bets

Our model's biggest edge in today's Pirates vs. Diamondbacks matchup is on the moneyline.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Video

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Pirates vs. Diamondbacks Game-Day Updates and Essential Details

Wednesday's MLB action between the Diamondbacks and Pirates at Chase Field is scheduled to commence at 3:40PM ET.

• Who: Pittsburgh Pirates vs. Arizona Diamondbacks
• Date: Wednesday, May 28, 2025
• Time: 3:40PM ET/12:40PM PT
• Venue: Chase Field

Dimers.com's comprehensive preview of Wednesday's Pirates vs. Diamondbacks matchup includes our prediction, picks and the latest betting odds.

Before making any Pittsburgh vs. Arizona picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Diamondbacks, with a 57% win probability, will likely beat the Pirates on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Pirates vs. Diamondbacks insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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